神经病学与神经康复学杂志2023，Vol.19Issue(2)：37-43,7.DOI:10.12022/jnnr.2023-0090
抗MDA5抗体阳性皮肌炎病例报告1例及文献回顾
A case report and review of a patient with anti MDA5 antibody positive dermatomyositis
摘要
Abstract
Objective:To evaluate the effect of combination of medical treatment and rehabilitation training on the recovery of patients with dermatomyositis. Methods:A retrospective review of the clinical data,the course of diagnosis and treatment,and the changes in the clinical status of 1 adult patient with anti MDA5 antibody positive dermatomyositis was conducted in conjunction with the relevant literature. Results:Anti MDA5 antibody positive dermatomyositis as a subtype of dermatomyositis with variable clinical presentation and rapid progression.It should be aggressively treated with combined immunosuppressive therapy.The patient in this case received multiple immunosuppressive therapies combined with rehabilitation training,and the therapeutic effect was good.Her weight was 37.5 kg at admission and 42.5 kg at discharge.Kubota water swallow test showed admission grade 4,recovery to grade 1 on discharge,and normal diet.Barthel index was 60 at admission and returned to 80 at discharge,and independent of stairs. Conclusion:Dermatomyositis is an occult chronic disease with multiple systemic involvement and poor muscle function in most patients.Establishment of an individualized early rehabilitation program facilitates functional recovery.关键词
皮肌炎/抗黑色素瘤分化相关基因5抗体/吞咽困难/康复训练Key words
Dermatomyositis/Anti melanoma differentiation related gene 5 antibody/Dysphagia/Rehabilitation引用本文复制引用
陈昌夏,胡公伟,白晨园,文卉子,吴毅,杨红..抗MDA5抗体阳性皮肌炎病例报告1例及文献回顾[J].神经病学与神经康复学杂志,2023,19(2):37-43,7.基金项目
国家自然科学基因青年项目(No.82201495) （No.82201495）
上海市卫健委面上项目(No 202140414)National Natural Science Gene Youth Project(82201495) （No 202140414）
Shanghai Municipal Health Commission General Project(202140414) （202140414）
