神经病学与神经康复学杂志2023，Vol.19Issue(2)：44-50,7.DOI:10.12022/jnnr.2023-0118
TDP-43在肌萎缩侧索硬化症中发病机制的研究
The pathogenesis of TDP-43 in amyotrophic lateral sclerosis
潘昊 1荆玮 2王呈蕙 2单悦童 2费智敏1
作者信息
- 1. 上海中医药大学附属曙光医院神经外科,上海 201203
- 2. 上海中医药大学附属曙光医院神经内科,上海 201203
- 折叠
摘要
Abstract
Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease that currently has no effective treatment,and its pathogenesis is unclear.Recent studies have found that transactive response element DNA binding protein-43(TDP-43)plays an important role in neurodegenerative diseases including ALS and frontotemporal dementia.This article summarizes the latest understanding of the structure of TDP-43 in the past decade,its role in the pathogenesis of neurodegenerative diseases,and potential therapeutic targets,in order to provide a basic research basis for the integrated diagnosis and treatment of ALS with Chinese and Western medicine.关键词
肌萎缩侧索硬化症/反式激活应答DNA结合蛋白43/谷氨酸受体/发病机制/治疗策略Key words
Amyotrophic lateral sclerosis/Trans active response element DNA binding protein 43/Glutamate receptor/Pathogenesis/Treatment strategies引用本文复制引用
潘昊,荆玮,王呈蕙,单悦童,费智敏..TDP-43在肌萎缩侧索硬化症中发病机制的研究[J].神经病学与神经康复学杂志,2023,19(2):44-50,7.
