神经病学与神经康复学杂志2023，Vol.19Issue(2)：51-57,7.DOI:10.12022/jnnr.2023-0114
药物外治法的进展以及在神经变性疾病中的应用
Progress in external therapy and its application in neurodegenerative diseases
摘要
Abstract
As a kind of transdermal drug delivery systems,external therapy can avoid first pass effect.It also has an advantage of releasing medicament steadily and direct acting on body surface,skeleton and muscle.As a common external therapy,plasters have complicated ingredients.The elements in plasters also absorb into the body in a different way from oral drug.How to make more drug penetrate through the skin as well as test the elements and concentrations that enter the body are still the main problems that quality control of plasters facing.The article summarizes the history of external therapy,particularly the plasters.Based on the researches in recent years,the article generalizes the penetration enhancers and methods which can promote the penetration rate and the way to detect the penetrate rate.The author introduces the advantages and usages of plasters in neurodegenerative diseases and hopes to provide brand new thinking that can help to improve the productions and uses of plasters.关键词
药物外治法/经皮给药/中药膏药/促透剂/透皮率/神经变性疾病Key words
External therapy/Transdermal drug delivery/Platers of traditional Chinese medicine/Penetration enhancers/Penetrate rate/Neurodegenerative diseases引用本文复制引用
单悦童,荆玮,王呈蕙,张海涵,潘卫东..药物外治法的进展以及在神经变性疾病中的应用[J].神经病学与神经康复学杂志,2023,19(2):51-57,7.基金项目
上海市浦东新区卫健委行业专项(PW2022E-03)Shanghai Pudong New Area Health Commission Industry Special Project(PW2022E-03) （PW2022E-03）
