四川精神卫生2024，Vol.37Issue(1)：52-56,5.DOI:10.11886/scjsws20230209001
产后精神分裂症患者临床特征分析
Clinical characteristics of patients with puerperal schizophrenia
卢晓桦 1李海静 1邝启杰 1易文英 1夏雨 1周女楠 1郑英君 1佘生林1
作者信息
- 1. 广州医科大学附属脑科医院,广东 广州 510370
- 折叠
摘要
Abstract
Background Women may develop severe symptoms of stress disorder following childbirth,which may be exposed to a risk of developing mental health problems,and even lead to the recurrence of the illness in female patients with schizophrenia,while comparatively limited research has been undertaken concerning the clinical characteristics and treatment of puerperal schizophrenia in China.Objective To explore the clinical characteristics of puerperal schizophrenia,so as to provide references for the clinical treatment.Methods A total of 24 patients with puerperal schizophrenia who were hospitalized in the female ward of adult psychiatry department of the Affiliated Brain Hospital of Guangzhou Medical University from 2012 to 2020 and met the Diagnostic and Statistical Manual of Mental Disorders,fourth edition(DSM-IV)diagnostic criteria for schizophrenia were included as puerperal group.Another 48 non-puerperal women with schizophrenia were concurrently enrolled as control group.Then the basic data,scores on Positive and Negative Symptom Scale(PANSS)and the discharge medication were recorded.Results The percentages of newly onset and positive family history of psychosis in puerperal group were larger than those in control group,with statistical significance(χ2=9.321,5.240,P<0.05 or 0.01).Puerperal group scored higher on PANSS excitement factor(t=-2.220,P<0.05)and lower on negative factor(t=3.377,P<0.01)compared with control group.In terms of discharge medication,puerperal group reported a higher dosage of antipsychotic drugs(t=-2.095,P<0.05),and a larger proportion of combined use of benzodiazepines or antidepressants(χ²=21.316,5.114,P<0.05 or 0.01)compared with control group,with statistical significance.Conclusion Patients with puerperal schizophrenia display increased ratings of excitement symptoms and decreased ratings of negative symptoms,which necessitates the use of high doses of antipsychotic drugs,and combined use of benzodiazepines and antidepressants.关键词
产后精神分裂症/临床特征/阳性症状/阴性症状Key words
Puerperal schizophrenia/Clinical characteristics/Positive symptoms/Negative symptoms分类
临床医学引用本文复制引用
卢晓桦,李海静,邝启杰,易文英,夏雨,周女楠,郑英君,佘生林..产后精神分裂症患者临床特征分析[J].四川精神卫生,2024,37(1):52-56,5.
