畜牧与兽医2024，Vol.56Issue(3)：23-30,8.
宫内发育迟缓仔猪断奶后肠道菌群特征及其与生长的潜在联系
Characteristics of gut microbiota and their potential association with growth in weaned piglets with intrauterine growth retardation
摘要
Abstract
This study was aimed to identify the characteristics of intestinal microbiota colonization and their potential association with organ growth and development in normal body weight(NBW)piglets and intrauterine growth retardation piglets(IUGR).Twelve NBW piglets and 12 IUGR piglets were selected for the experiment.The piglets were weaned at 21 days of age,and then were fed individually.After 7 days of adaptation,a 28-day feeding experiment was conducted.At the end of the experiment,the piglets were slaughtered and their liver,spleen and pancreas were separated and weighed.Their jejunum,ileum,and colon were also separated and weighed.The contents of the jejunum,ileum,and colon were collected for microbiome sequencing.The results showed that,compared with those of the NBW piglets,the final weight,liver weight,jejunum weight and length of the IUGR piglets were significantly decreased(P＜0.05).However,theirliverindex;ile-um weight,length and the index;and colon weight length and the index were significantly increased(P＜0.05).The microbiota α and β di-versity of the jejunum,ileum,and colon in the NBW piglets and IUGR piglets did not vary significantly;but the jejunal Proteobacteria abun-dance in the IUGR piglets was increased(P=0.08),their Ileal Proteobacteria and Actinobacteria abundances were significantly increased(P＜0.05),and their Firmicutes abundance was significantly decreased(P＜0.05).Furthermore,the spearman correlation analysis showed that the intestinal differential microbiota was closely correlated with the organ development of the piglets,and there were significant negative correlations(P＜0.05)between their jejunal Staphylococcus and final weight,liver weight,and pancreas weight;and between their ileal Fir-micutes and ileal weight,length,and index.There were significant positive correlations(P＜0.05)between ileal Proteobacteria and ileal weight,ileal index and liver index;and between colonic Actinobacteria with colonic weight and index.In conclusion,these results indicated that the intestinal microbial colonization in the NBW piglets and IUGR piglets varied significantly after weaning,which was significantly cor-related with the organ growth and development of the piglets.关键词
宫内发育迟缓/断奶仔猪/肠道微生物/生长发育Key words
intrauterine growth retardation/weaned piglets/gut microbiota/growth and development分类
农业科技引用本文复制引用
刘洋,孔祥峰,余祖功..宫内发育迟缓仔猪断奶后肠道菌群特征及其与生长的潜在联系[J].畜牧与兽医,2024,56(3):23-30,8.基金项目
国家自然科学基金联合基金重点支持项目(U20A2056) （U20A2056）
