中国组织工程研究2024，Vol.28Issue(31)：5048-5054,7.DOI:10.12307/2024.715
炎症环境下白细胞介素1β增强间充质干细胞的迁移及黏附能力
Interleukin-1beta enhances migration and adhesion of mesenchymal stem cells in inflammatory environments
摘要
Abstract
BACKGROUND:Mesenchymal stem cells possess characteristics such as rapid renewal,targeted homing,tissue repair,and immune regulation,which provide potential for the treatment of inflammatory diseases.In most inflammatory diseases,interleukin-1β is highly expressed.Both exogenous and endogenous mesenchymal stem cells unavoidably exist in an environment with high interleukin-1β concentration. OBJECTIVE:To study the interaction of interleukin-1β with mesenchymal stem cells in inflammatory environment and the mechanism of its influence on the migration and adhesion of mesenchymal stem cells to provide a theoretical basis for adjusting stem cell therapy strategies. METHODS:The first author searched for studies involving interleukin-1β enhancing migration and adhesion of mesenchymal stem cells by computer on CNKI,WanFang,VIP,PubMed,and Web of Science using search terms"interleukin-1β,mesenchymal stem cell,nuclear factor-κB,MAPK,ERK,p38,migration,adhesion"in Chinese and English.The literature tracing method was also used to search for some of the literature.Finally,65 articles were included in the review analysis. RESULTS AND CONCLUSION:(1)In the inflammatory environment,interleukin-1β can regulate the migration and adhesion ability of mesenchymal stem cells.This effect may be achieved by recruiting IRAK1 through interleukin-1RI and then activating TAK1 and IKK in turn.After IKK phosphorylation,nuclear factor-κB and ERK signaling pathways are activated or CXCR expression is upregulated through the p38 pathway to promote mesenchymal stem cell migration and adhesion.However,further standardized research needs to be carried out based on the genetic background of mesenchymal stem cells,the dose and processing time of interleukin-1β.(2)In vitro experiments using pre-stimulated mesenchymal stem cells with interleukin-1β can change the survival environment of mesenchymal stem cells and alter their secretion factors to make them develop towards a more anti-inflammatory direction.On the other hand,under the premise of producing higher levels of anti-inflammatory and pro-nutrient factors,extracted mesenchymal stem cell exosomes can exert anti-inflammatory effects.(3)It has been observed in various animal disease models that pre-stimulating mesenchymal stem cells with interleukin-1β regulates their immune regulation ability,thereby affecting the development and outcome of inflammation.However,this is limited to preclinical basic research only;further verification on efficacy and safety of stem cell therapy with interleukin-1β pre-treated mesenchymal stem cells is required in clinical settings.关键词
白细胞介素1β/间充质干细胞/炎症/迁移/黏附/信号通路/核转录因子κB/MAPK/ERK/p38Key words
interleukin 1β/mesenchymal stem cell/inflammation/migration/adhesion/signaling pathway/nuclear factor-κB/MAPK/ERK/p38分类
医药卫生引用本文复制引用
吴齐翔,房辰雨,张蕾..炎症环境下白细胞介素1β增强间充质干细胞的迁移及黏附能力[J].中国组织工程研究,2024,28(31):5048-5054,7.基金项目
国家自然科学基金项目(81660303),项目负责人:张蕾 （81660303）
云南省大学生创新创业训练计划(S202210674078),项目负责人:吴齐翔National Natural Science Foundation of China,No.81660303(to ZL) （S202210674078）
Innovation and Entrepreneurship Training Program for College Students in Yunnan Province,No.S202210674078(to WQX) （to WQX）
