中国组织工程研究2024，Vol.28Issue(31)：5063-5069,7.DOI:10.12307/2024.723
外泌体微小RNA与骨关节疾病:作用与机制
Exosome-derived microRNA with bone and joint diseases:role and mechanism
摘要
Abstract
BACKGROUND:Exosomes are vesicle-like structures secreted by cells into extracellular compartments in the form of cytosol,which contain a large amount of microRNAs with important intercellular communication roles.MicroRNAs in exosomes rely on exosome transport and are able to enter target cells to exert important biological regulatory effects.In common bone and joint diseases,abnormal or damaged bone metabolism releases a large number of exosomes,while some exosome-derived microRNAs also promote the progression of osteoarthritis.Therefore,exosome-derived microRNAs are closely related to the skeletal system and are important for the development as well as diagnosis and treatment of many osteoarticular diseases. OBJECTIVE:To review the research progress of exosome-derived microRNAs in bone metabolism and bone and joint diseases. METHODS:Using"exosomes,extracellular vesicle,microRNA,miRNA,bone,bone diseases,bone formation,bone regeneration,bone resorption,bone destruction"as Chinese and English search terms,articles were searched on CNKI,Metasys,and PubMed databases.Finally,86 articles were included for summarization. RESULTS AND CONCLUSION:Exosome-derived microRNAs can regulate bone metabolism by affecting bone formation and bone resorption,and are closely related to the development of bone and joint diseases such as fracture healing,osteoporosis,osteoarthritis,rheumatoid arthritis,osteonecrosis of the femoral head,and osteosarcoma.Exosome-derived microRNAs will be an effective means of diagnosis and treatment of certain bone and joint diseases in the future.However,the current research on exosome-derived microRNAs in osteoarthritic diseases is limited,and more explorations and researches are still needed to diagnose and treat osteoarthritic diseases using exosome-derived microRNAs.关键词
外泌体/微小RNA/骨关节疾病/骨形成/骨吸收/骨折/骨质疏松/关节炎/股骨头坏死/骨肉瘤Key words
exosome/microRNA/bone and joint diseases/bone formation/bone resorption/fracture/osteoporosis/arthritis/femoral head necrosis/osteosarcoma分类
医药卫生引用本文复制引用
袁平,王志华,王伟舟,王文通,何飞..外泌体微小RNA与骨关节疾病:作用与机制[J].中国组织工程研究,2024,28(31):5063-5069,7.基金项目
国家自然科学基金地区科学基金项目(82160417),项目负责人:何飞 （82160417）
云南省应用基础研究(昆医联合专项重点项目)(202101AY070001-013),项目负责人:何飞 （昆医联合专项重点项目）
云岭产业技术领军人才(YLXL20170046),项目负责人:何飞National Natural Science Foundation of China(Regional Project),No.82160417(to HF) （YLXL20170046）
Applied Basic Research in Yunnan Province(Key Project of Kunming Medical University Joint Project),No.202101AY070001-013(to HF) （Key Project of Kunming Medical University Joint Project）
Cloud-Ridge Industry Technology Leader Grant,No.YLXL20170046(to HF) （to HF）
