摘要
Abstract
Myelodysplastic syndrome(MDS)is a relatively common group of myeloid malignant clonal diseases in the blood system.Different types of MDS patients have different clinical manifestations and natural course,as well as the it-erations of different classification systems and versions in history,resulting distress in diagnosis,classification and treat-ment options.With the advancement of molecular biology technology and the use of Lenalidomide,Luspatercept,Veneto-clax and other drugs,the classification criteria and prognostic scoring system of myelodysplastic syndrome have been con-tinuously refined in recent years.In the 2016 WHO classification criteria,a molecular-related classification criterion(SF3B1)was introduced for the first time,and 5q-was redefined,emphasizing the concept of driver mutation.The 2022 WHO classification standard has more prominent molecular biological characteristics based on the original,and the classifi-cation of SF3B1 and 5q-has also been retained in the 2022 WHO classification standard.A new molecular correlation clas-sification standard(bi-TP53)has been added to the 2022 WHO classification standard to further improve the classification of MDS patients by clinicians and researchers,reflecting the new trend of future genomics research that guide the precision medicine treatment of MDS.At the same time,the prognostic scoring system for MDS patients is constantly being updated.Based on the Revised International Prognostic Scoring System(IPSS-R)for Myelodysplastic Syndromes proposed in 2012,the newly proposed Molecular International Prognostic Scoring System(IPSS-M)for myelodysplastic Syndrome introduces a new prognostic scoring system for MDS patients,the stratification of risk factors in MDS patients is more precise and indi-vidualized.With the improvement of molecular targeted drugs and testing technology,IPSS-M will continue to be updated.To this end,we will summarize the classification criteria of MDS in recent years,as well as the progress and clinical signifi-cance of the prognostic stratification system.关键词
MDS分型/WHO标准/ICC标准/IPSS-M系统Key words
MDS typing/WHO standards/ICC standards/IPSS-M system分类
医药卫生
