摘要
Abstract
The Global Burden of Bacterial Infections report showed that in 2019,there were approximately 13.7 mil-lion deaths worldwide due to infection(95%UI ranging from 10.9 million to 17.1 million),and bacterial infection related deaths accounted for 13.6%(10.1%-18.1%)of global deaths,making it the second leading cause of death globally,second only to ischemic heart disease.Eleven infectious syndromes involve 33 bacterial pathogens and are associated with 7.7 mil-lion deaths worldwide(5.7 million to 10.2 million).Lower respiratory tract infections have caused approximately 4 million deaths worldwide(3.33 million to 4.89 million),with Streptococcus pneumoniae causing the most deaths at 653 000(553 000 to 777 000);Blood flow infections have caused 2.91 million people(1.74 million to 4.53 million),with Staphylococcus aureus causing the most deaths,at 299 000 people(166 000 to 485 000);Peritoneal and intra-abdominal infections have caused 1.28 million deaths(826 000 to 1.86 million),with Escherichia coli causing the most deaths,reaching 290000(188 000 to 423 000).The Global Burden of Bacterial Infections report also shows that in 2019,Staphylococcus aureus was associated with over 1 million deaths(resulting in 1.105 million deaths);Escherichia coli causes 450 000(329 000 to 602 000)female and 500 000(355 000 to 684 000)male deaths worldwide,while Streptococcus pneumoniae causes over 750 000 deaths worldwide;Klebsiella pneumoniae causes over 750 000 deaths worldwide;Pseudomonas aeruginosa has caused over 500 000 deaths worldwide.The Global Burden of Bacterial Infections report data shows that the pathogens most associated with mortality worldwide vary by age.Staphylococcus aureus is the deadliest pathogen among people aged 15 and above,with 940 000 deaths(682 000 to 1 276 000)in this age group;Salmonella typhi is most associated with mortality in children aged 5-14,with a death toll of 49 000(23 000-86 000);Streptococcus pneumoniae is most associated with the death of new-borns to 4-year-old children,with a death toll of 225 000(180 000 to 281 000).The Global Burden of Bacterial Infections report estimates the mortality rates of various pathogens and infectious syndromes,some of which were previously unknown and some were severely underestimated,especially in low-and middle-income countries where the burden is disproportion-ately high.However,there is a lack of corresponding data and research in China,and it is necessary to conduct correspond-ing surveys and research to develop innovative strategies.关键词
感染性综合征/细菌病原体/死亡率/寿命损失年Key words
Infectious syndrome/Bacterial pathogens/Mortality rate/Life loss year分类
医药卫生
