中国当代儿科杂志2024，Vol.26Issue(2)：139-144,6.DOI:10.7499/j.issn.1008-8830.2306040
267例儿童嗜酸粒细胞性胃肠道疾病临床特征分析:一项多中心研究
Clinical characteristics of 267 children with eosinophilic gastrointestinal disease:a multicenter study
摘要
Abstract
Objective To explore the clinical manifestations,endoscopic findings,histopathological changes,treatment,and prognosis of eosinophilic gastrointestinal disease(EGID)in children,with the aim of enhancing awareness among pediatricians about this condition.Methods Data of 267 children with EGID were prospectively collected from January 2019 to July 2022 at Jiangxi Children's Hospital,Hunan Children's Hospital,and Henan Children's Hospital.The age of onset,symptoms,physical signs,laboratory examination results,endoscopic findings,histopathological changes,and treatment outcomes were observed.Results Among the 267 children with EGID,the majority had mild(164 cases,61.4% )or moderate(96 cases,35.6% )clinical severity.The disease occurred at any age,with a higher prevalence observed in school-age children(178 cases).The main symptoms in infants were vomiting and hematemesis,while in toddlers,vomiting and bloody stools were prominent.Abdominal pain and vomiting were the primary symptoms in preschool and school-age children.Nearly half(49.4% )of the affected children showed elevated platelet counts on hematological examination,but there was no significant difference in platelet counts among children with mild,moderate,and severe EGID(P>0.05).Endoscopic findings in EGID children did not reveal significant specificity,and histopathological examination showed no specific structural damage.Among them,85.0% (227 cases)received acid suppression therapy,34.5% (92 cases)practiced dietary avoidance,20.9% (56 cases)received anti-allergic medication,and a small proportion(24 cases,9.0% )were treated with prednisone.Clinical symptoms were relieved in all patients after treatment,but three cases with peptic ulcers experienced recurrence after drug discontinuation.Conclusions Mild and moderate EGID are more common in children,with no specific endoscopic findings.Dietary avoidance,acid suppression therapy,and anti-allergic medication are the main treatment methods.The prognosis of EGID is generally favorable in children.[Chinese Journal of Contemporary Pediatrics,2024,26(2):139-144]关键词
嗜酸粒细胞性胃肠道疾病/临床特征/儿童Key words
Eosinophilic gastrointestinal disease/Clinical characteristic/Child引用本文复制引用
詹春雷,游洁玉,李小芹,汪勇,梅贤琴,万盛华..267例儿童嗜酸粒细胞性胃肠道疾病临床特征分析:一项多中心研究[J].中国当代儿科杂志,2024,26(2):139-144,6.基金项目
江西省科技计划项目重点研发计划(20192BBG70002). （20192BBG70002）
