中国当代儿科杂志2024，Vol.26Issue(2)：145-150,6.DOI:10.7499/j.issn.1008-8830.2307011
血红蛋白下降值对晚发型败血症早产儿继发坏死性小肠结肠炎的预测价值
Predictive value of hemoglobin decrease for necrotizing enterocolitis in preterm infants with late-onset sepsis
摘要
Abstract
Objective To study the predictive value of hemoglobin(Hb)decrease for the occurrence of necrotizing enterocolitis(NEC)in preterm infants with late-onset sepsis(LOS).Methods Clinical data of 93 LOS preterm infants were collected for retrospective analysis,among which 16 infants developed NEC while 77 infants did not.Based on the decrease in Hb levels from the most recent Hb measurement before LOS occurrence to the initial Hb levels during LOS,the infants were divided into three groups:no Hb decrease(n=15),mild Hb decrease(Hb decrease<15 g/L;n=35),and severe Hb decrease(Hb decrease≥15 g/L;n=43).Multivariate logistic regression analysis was conducted to explore the predictive factors for NEC secondary to LOS,and the value of Hb decrease in predicting NEC secondary to LOS was evaluated through receiver operating characteristic curve analysis.Results The incidence of NEC in the severe Hb decrease group,mild Hb decrease group,and no Hb decrease group were 26% ,14% ,and 0% (P<0.05),respectively.Multivariate logistic regression analysis revealed that a larger Hb decrease was an independent predictive factor for NEC in LOS preterm infants(OR=1.141,95% CI:1.061-1.277,P<0.001).Receiver operating characteristic curve analysis showed that the area under the curve for predicting NEC in preterm infants with LOS using Hb decrease(with a cut-off value of 20 g/L)was 0.803,with sensitivity and specificity of 0.69 and 0.78,respectively.Conclusions Hb decrease can serve as an indicator for prediction of NEC in preterm infants with LOS.[Chinese Journal of Contemporary Pediatrics,2024,26(2):145-150]关键词
晚发型败血症/坏死性小肠结肠炎/血红蛋白/早产儿Key words
Late-onset sepsis/Necrotizing enterocolitis/Hemoglobin/Preterm infant引用本文复制引用
蔡娜,沈蕾蕾,陈盛..血红蛋白下降值对晚发型败血症早产儿继发坏死性小肠结肠炎的预测价值[J].中国当代儿科杂志,2024,26(2):145-150,6.基金项目
国家自然科学基金项目(82301956、82170565). （82301956、82170565）
