中国当代儿科杂志2024，Vol.26Issue(2)：158-163,6.DOI:10.7499/j.issn.1008-8830.2309090
人绒毛膜促性腺激素激发试验在性发育异常儿童中的诊断作用评估
Value of the human chorionic gonadotropin stimulation test in the diagnosis of disorder of sexual development in children
摘要
Abstract
Objective To investigate the value of the human chorionic gonadotropin(hCG)stimulation test in the diagnosis of disorder of sexual development(DSD)in children.Methods A retrospective analysis was conducted on 132 children with DSD.According to the karyotype,they were divided into three groups:46,XX group(n=10),46,XY group(n=87),and sex chromosome abnormality group(n=35).The above groups were compared in terms of sex hormone levels before and after hCG stimulation test,and the morphological manifestation of the impact of testicular tissue on the results of the hCG stimulation test was analyzed.Results There was no significant difference in the multiple increase of testosterone after stimulation among the three groups(P>0.05).In the 46,XY group,the children with 5α-reductase type 2 deficiency had a testosterone-to-dihydrotestosterone ratio higher than that of the 46,XY DSD children with other causes.Morphological analysis showed that DSD children with testicular tissue demonstrated a significantly higher multiple increase in testosterone after stimulation compared to children without testicular tissue(P<0.05).Conclusions The hCG stimulation test has an important value in assessing the presence and function of testicular interstitial cells in children with different types of DSD,and it is recommended to perform the hCG stimulation test for DSD children with unclear gonadal type.[Chinese Journal of Contemporary Pediatrics,2024,26(2):158-163]关键词
性发育异常/人绒毛膜促性腺激素激发试验/睾丸间质细胞/睾酮/儿童Key words
Disorder of sexual development/Human chorionic gonadotropins stimulation test/Testicular interstitial cell/Testosterone/Child引用本文复制引用
梁翠丽,刘国昌,程静,牛会林,伏雯,张丽瑜,贾炜,张文,刘丽..人绒毛膜促性腺激素激发试验在性发育异常儿童中的诊断作用评估[J].中国当代儿科杂志,2024,26(2):158-163,6.基金项目
中国儿童生长发育学术交流专项基金(Z-2019-41-2101-01) （Z-2019-41-2101-01）
广州市卫生健康科技项目(20231A010024). （20231A010024）
