中国当代儿科杂志2024，Vol.26Issue(2)：164-168,5.DOI:10.7499/j.issn.1008-8830.2309033
儿童IgA血管炎肾炎伴高凝状态的尿蛋白和肾脏病理特征分析
Urinary protein and renal pathological features in children with immunoglobulin A vasculitis with nephritis and hypercoagulability
摘要
Abstract
Objective To study the association of hypercoagulability with urinary protein and renal pathological damage in children with immunoglobulin A vasculitis with nephritis(IgAVN).Methods Based on the results of coagulation function,349 children with IgAVN were divided into a hypercoagulability group consisting of 52 children and a non-hypercoagulability group consisting of 297 children.Urinary protein and renal pathological features were compared between the two groups,and the factors influencing the formation of hypercoagulability in children with IgAVN were analyzed.Results Compared with the non-hypercoagulability group,the hypercoagulability group had significantly higher levels of urinary erythrocyte count,24-hour urinary protein,urinary protein/creatinine,urinary immunoglobulin G/creatinine,and urinary N-acetyl-β-D-glucosaminidase(P<0.05).The hypercoagulability group also had a significantly higher proportion of children with a renal pathological grade of Ⅲ-Ⅳ,diffuse mesangial proliferation,capillary endothelial cell proliferation,or>25％ crescent formation(P<0.05).The multivariate logistic regression analysis showed that capillary endothelial cell proliferation and glomerular crescent formation>25％ were associated with the formation of hypercoagulability in children with IgAVN(P<0.05).Conclusions The renal injury in IgAVN children with hypercoagulability is more severe,with greater than 25％ crescent formation and increased proliferation of glomerular endothelial cells being important contributing factors that exacerbate the hypercoagulable state in IgAVN.[Chinese Journal of Contemporary Pediatrics,2024,26(2):164-168]关键词
IgA血管炎肾炎/蛋白尿/肾脏病理/高凝状态/儿童Key words
Immunoglobulin A vasculitis with nephritis/Proteinuria/Renal pathology/Hypercoagulability/Child引用本文复制引用
白梦刻,杨晓青,梅晓峰,李金刚,杨月丽,黄岩杰..儿童IgA血管炎肾炎伴高凝状态的尿蛋白和肾脏病理特征分析[J].中国当代儿科杂志,2024,26(2):164-168,5.基金项目
国家自然科学基金项目(82174187) （82174187）
河南省中医药学科领军人才项目(豫卫中医函[2021]8号) （豫卫中医函[2021]8号）
河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020008). （STG-ZYXKY-2020008）
