肿瘤代谢标志物在肺癌液体活检中的研究进展OA北大核心CSTPCD

Liquid biopsy is gradually being applied in the clinical diagnosis and treatment of lung cancer.At pres-ent,with the development of metabolomics,more and more metabolic biomarkers are considered as potential sensitive mark-ers reflecting the occurrence and development of tumors.This article summarizes the changes in the main metabolic pathways of lung cancer,including glucose metabolism,amino acid metabolism,lipid metabolism,sphingolipid metabolism,glycero-phospholipid metabolism,and purine metabolism.Meanwhile,this article reviews the role of metabolic biomarkers in the early diagnosis of lung cancer,predicting disease progression,and evaluating the efficacy of chemotherapy and immunotherapy,aim-ing to provide effective biomarkers for tumor diagnosis and treatment.