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可切除非小细胞肺癌新辅助免疫治疗研究进展

齐畅 田攀文 李为民

中国肺癌杂志2024,Vol.27Issue(2):138-146,9.
中国肺癌杂志2024,Vol.27Issue(2):138-146,9.DOI:10.3779/j.issn.1009-3419.2024.102.06

可切除非小细胞肺癌新辅助免疫治疗研究进展

Progress on Neoadjuvant Immunotherapy for Resectable Non-small Cell Lung Cancer

齐畅 1田攀文 2李为民3

作者信息

  • 1. 610041 成都,四川大学华西医院呼吸与危重症医学科,呼吸和共病全国重点实验室,精准医学四川省重点实验室
  • 2. 610041 成都,四川大学华西医院呼吸与危重症医学科,呼吸和共病全国重点实验室,精准医学四川省重点实验室||四川大学华西医院肺癌中心
  • 3. 610041 成都,四川大学华西医院呼吸与危重症医学科,呼吸和共病全国重点实验室,精准医学四川省重点实验室||四川大学华西医院呼吸健康研究所,疾病分子网络前沿科学中心,呼吸和共病研究院||四川大学华西医院中国医学科学院创新单元
  • 折叠

摘要

Abstract

In recent years,there has been a consensus regarding the enhancement of prognosis in patients with ad-vanced non-small cell lung cancer(NSCLC)through the utilization of immune checkpoint inhibitors(ICIs).Numerous clini-cal studies have also demonstrated the substantial value of immunotherapy for resectable NSCLC patients.Nevertheless,there remain controversies surrounding the exploration of immune combination strategies,treatment-related side effects,prognostic biomarkers,as well as other issues in the neoadjuvant therapy setting.Consequently,this article presents a comprehensive overview of the recent advancements in neoadjuvant immunotherapy for resectable NSCLC,stimulating fresh perspectives and delving into its merits and challenges in clinical application.

关键词

肺肿瘤/新辅助治疗/免疫检查点抑制剂/围手术期/可切除非小细胞肺癌

Key words

Lung neoplasms/Neoadjuvant therapy/Immune checkpoint inhibitors/Perioperative period/Resect-able non-small cell lung cancer

引用本文复制引用

齐畅,田攀文,李为民..可切除非小细胞肺癌新辅助免疫治疗研究进展[J].中国肺癌杂志,2024,27(2):138-146,9.

基金项目

TThis paper was supported by the grants from National Natural Science Foundation of China(No.82072598,to Pan-wen TIAN ()

No.92159302,to Weimin LI),Science and Technology Project of Sichuan,China(No.2022ZDZX0018)(to Wei-min LI),and 1-3-5 project for disciplines of excellence,West China Hospital,Sichuan University,China(No.ZYJC21052,to Panwen TIAN (No.2022ZDZX0018)

No.ZYGD22009,to Weimin LI). 本文受国家自然科学基金项目(No.82072598,No.92159302)、四川省科技厅重大专项(No.2022ZDZX0018)和四川大学华西医院1-3-5卓越计划项目(No.ZYJC21052,No.ZYGD22009)资助 (No.82072598,No.92159302)

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