中国临床药理学与治疗学2024，Vol.29Issue(3)：328-333,6.DOI:10.12092/j.issn.1009-2501.2024.03.011
艾司氯胺酮的药理学特性及其在小儿麻醉中的应用进展
Pharmacological characteristics of esketamine and its application progress in pediatric anesthesia
摘要
Abstract
Esketamine is an antagonist of the N-methyl-D-aspartate(NMDA)receptor and exerts an-tianxiety,hypnotic,sedative,and analgesic effects by interacting with NMDA receptors,opioid recep-tors,M-choline receptors,monoamine receptors,adenosine receptors,and other purine receptors.As the more potents isomer of ketamine,it is about twice as potent as ketamine.Compared with ketamine,esketamine has the characteristics of rap-id onset and metabolism,strong analgesia,slight respiratory depression,rapid recovery of cognitive function,and low incidence of psychiatric side ef-fects.It has become a new choice of pediatric anes-thesia drugs.This article reviews the pharmacologi-cal properties of esketamine and its recent applica-tion in pediatric anesthesia,and provides reference for the safe use of esketamine in pediatric perioper-ative period.关键词
艾司氯胺酮/镇静/镇痛/小儿Key words
esketamine/sedative/analgesia/pe-diatric分类
医药卫生引用本文复制引用
金宝伟,郭建荣..艾司氯胺酮的药理学特性及其在小儿麻醉中的应用进展[J].中国临床药理学与治疗学,2024,29(3):328-333,6.基金项目
浙江省公益技术应用研究资助项目(LGD22H160011) （LGD22H160011）
