儿童肺部侵袭性曲霉菌感染的诊治进展OA北大核心CSTPCD

Aspergillus is widely distributed in nature.When the temperature and humidity are suitable,Aspergillus can grow into hyphae and produce conidia,which can colonize the human respiratory tract through air transmission.When in the host's immune function is low,the diseases related to pathogenic Aspergillus are likely to develop,most of which are lung involvement,that is,invasive pulmonary aspergillosis(invasive pulmonary aspergillosis,IPA).Compared with adult patients,the imaging manifestations of children with IPA are more atypical,and the current research on serological markers is not sufficient,making the diagnosis of IPA in children mostly difficult.At the same time,antifungal medications that are safe for children remain to be explored.Therefore,this article reviews epidemiology,pathogenic mechanism,clinical manifestations,diagnostic techniques,and treatment of IPA in children.