中国兽医科学2024，Vol.54Issue(2)：261-266,6.DOI:10.16656/j.issn.1673-4696.2024.0027
宿主蛋白SIRT5在代谢和疾病进程中的作用
Role of host protein SIRT5 in metabolism and disease processes
摘要
Abstract
As a member of the Sirtuins family,SIRT5 is a lysine deacylase dependent on nicotinamide adenine dinucleotide(NAD),with deacetylation,desuccinylation,demalonylation and deglutarylation activities.SIRT5 is an important regulator of cell homeostasis,regulating the activity of proteins involved in different metabolic processes,such as glycolysis,tricarboxylic acid cycle(TCA cycle),fatty acid-β oxidation,and reactive oxygen species(ROS)detoxification.SIRT5 can also act as a tumor activator or suppressor,which plays an important role in neurode-generative diseases.In addition,SIRT5 also plays a key role in the antiviral innate immune response.In this paper,the structure,enzyme activity,biological function and the role of SIRT5 in the disease process were reviewed,so as to comprehensively understand the research status of SIRT5.关键词
SIRT5/酶活性/代谢/肿瘤/天然免疫Key words
SIRT5/enzymatic activity/metabolism/tumour/innate immunity分类
农业科技引用本文复制引用
陈国辉,赵思越,何路,刘湘涛,郑海学,张克山,史喜绢,杨行,张大俊,赵登率,闫文倩,陈玲玲,别鑫恬,赵美玉..宿主蛋白SIRT5在代谢和疾病进程中的作用[J].中国兽医科学,2024,54(2):261-266,6.基金项目
国家重点研发计划项目(2021YFD1800300) （2021YFD1800300）
国家生猪产业技术体系项目(CARS-35) （CARS-35）
甘肃省科技重大专项(21ZD3NA001-5) （21ZD3NA001-5）
中国农业科学院重大任务(CAAS-ZDRW202006-03) （CAAS-ZDRW202006-03）
