中华神经创伤外科电子杂志2023，Vol.9Issue(5)：277-282,6.DOI:10.3877/cma.j.issn.2095-9141.2023.05.004
急性颅脑损伤继发下肢静脉血栓的相关危险因素分析及预测模型构建
Analysis of related risk factors and construction of prediction model for venous thrombosis of lower limbs secondary to acute traumatic brain injury
摘要
Abstract
Objective To analyze the relevant risk factors of lower limb venous thrombosis(VET)secondary to acute traumatic brain injury(TBI)and establish a predictive model.Methods A retrospective study was conducted on 200 acute TBI patients who underwent Neurosurgery Department of Bethune Hospital,Shanxi Medical University January 2020 to September 2022.General information,imaging data,and test indicators of the patients were collected 24 h after admission.Based on the results of lower limb ultrasound examination during hospitalization,the patients were divided into VTE group(54 cases)and non VTE group(146 cases).The various indicators of the two groups of patients were compared,the independent risk factors for lower limb VET in TBI patients were analyzed,and the risk prediction model was established.The predictive value of the model was evaluated by drawing ROC curves.Results There were statistically significant differences in age,white blood cell count,neutrophil count,platelet count,admission GCS≤8 score,and lower limb immobilization between VTE group and the non VTE group(P＜0.05).The multivariate Logistic regression analysis showed that age,admission GCS≤8 score,and lower limb immobilization were independent risk factors for lower limb VET in patients with acute TBI(P＜0.05).A column chart prediction model was constructed using risk factors.ROC curve analysis showed that the area under the curve for lower limb VET in TBI patients diagnosed with age,admission GCS≤8 score,and lower limb immobilization were 0.716(95％CI:0.642-0.791),0.407(95％CI:0.341-0.500),and 0.596(95％CI:0.501-0.691),respectively.The AUC value of the model(represented by the combined variable PRE)was 0.770(95％CI:0.698-0.841),indicating that the model has a good predictive effect on lower limb VET in TBI patients.Conclusion Age,lower limb immobilization,and admission GCS≤8 score are independent risk factors for lower limb VET in acute TBI patients,and the constructed risk prediction model has certain predictive value.关键词
急性颅脑损伤/下肢静脉血栓/危险因素/预测模型Key words
Acute traumatic brain injury/Lower limb venous thrombosis/Risk factors/Prediction model引用本文复制引用
李飞翔,段虎斌,李晋虎,吴昊,王永红,范益民..急性颅脑损伤继发下肢静脉血栓的相关危险因素分析及预测模型构建[J].中华神经创伤外科电子杂志,2023,9(5):277-282,6.基金项目
Research Subject of Shanxi Provincial Health Commission(2019005)山西省卫生健康委科研课题(2019005) （2019005）
