摘要
Abstract
Objective To construct a risk stratification framework and nomogram for predicting the survival of intracranial germ cell tumors based on the SEER database.Methods The surveillance,epidemiology,and end results(SEER)database was used to collect demographic,survival,and treatment information for patients diagnosed with intracranial germinoma simplex from January 2000 to December 2019.Kaplan-Meier curve and Cox proportional risk model were used to evaluate the survival mode,and a nomogram was designed to evaluate the prognosis of patients with simple intracranial germ-cell tumor.The concordance index(C-index)was used to evaluate the accuracy of the prediction model.Results A predictive model for 3-year and 5-year overall survival(OS)of patients with intracranial simple germ cell tumors was constructed based on factors such as age,gender,race,radiation therapy,chemotherapy,and surgery.The nomogram C-index was 0.64.The risk score calculated based on the nomogram were divided into low-risk scores(≥140.67 points)and high-risk scores(＜140.67 points).Kaplan Meier survival curve analysis showed that patients younger than 20 years old,receiving chemotherapy and low-risk score showed a longer survival period,and the difference was statistically significant(P＜0.05).However,there was no statistically significant difference in the impact of gender,race,radiation therapy,and surgical treatment on the overall survival rate of patients(P＞0.05).Conclusion The construction of nomogram and risk stratification mechanism for survival prediction of patients with primary intracranial germinoma is helpful for clinicians to predict the OS in patients with simple intracranial germinoma.关键词
颅内生殖细胞瘤/生殖细胞瘤/生存预测/SEER数据库Key words
Intracranial germ cell tumor/Germinoma/Survival prediction/SEER database
