摘要
Abstract
Objective To analyze the diagnostic value of color Doppler ultrasound blood flow parameters,serum uric acid and cystatin C(CysC)for carotid stenosis in patients with transient ischemic attack(TIA).Methods A total of 126 TIA patients were prospectively selected from January 2020 to September 2022 in Ultrasound Diagnostic Department of the 82nd Group Military Hospital of PLA.They were divided into a normal group(32 patients),a mild group(50 patients),and a moderate and severe group(44 patients)according to the degree of carotid stenosis.TCD blood flow parameters,serum uric acid,and CysC levels were compared among three groups.The binary Logistic regression was used to analyze the factors affecting carotid artery stenosis in TIA patients,and the receiver operating characteristic(ROC)curve was established to evaluate the value of color Doppler ultrasound blood flow parameters,serum uric acid and CysC in diagnosing carotid artery stenosis in TIA patients individually and jointly,and in differentiating the degree of stenosis.Results The peak systolic flow velocity(PSV),end diastolic flow velocity(EDV),mean flow velocity(MFV),uric acid and CysC levels of patients in the moderate and severe groups were significantly higher than those in the mild group and the normal group(P＜0.05).Binary Logistic regression analysis showed that diabetes,PSV,uric acid and CysC were independent risk factors for carotid stenosis in TIA patients(P＜0.05).The ROC curve results showed that the area under the curve(AUC)of carotid artery stenosis in TIA patients diagnosed by PSV,uric acid and CysC respectively and jointly was 0.964,0.814,0.810 and 0.971.The AUC of carotid artery stenosis degree in TIA patients was 0.808,0.692,0.666 and 0.815 respectively and jointly identified by PSV,uric acid and CysC.Conclusion The PSV,EDV,MFV,uric acid and CysC levels of TIA patients with carotid stenosis were abnormally increased,and the higher the severity of stenosis was,the more obvious the increase was.The combination of PSV,uric acid and CysC has certain reference value for clinical diagnosis and differential diagnosis of carotid stenosis in TIA patients.关键词
短暂性脑缺血发作/颈动脉狭窄/彩色多普勒超声/血流参数/尿酸/胱抑素CKey words
Transient ischemic attack/Carotid artery stenosis/Color Doppler ultrasound/Blood flow parameters/Uric acid/Cystatin C
