曹世欢 1梁婉娴 1张丽宁 1刘霞 2刘春晖 2王萍1
作者信息
- 1. 北京中医药大学循证医学中心,北京 100029
- 2. 北京国铭博思医药科技有限公司,北京 100036
- 折叠
摘要
Abstract
Objective To evaluate the efficacy,safety and economy of Chinese patent medicines(Lianhua Qingwen capsules(granules),Jinhua Qinggan granules,Xuanfei Baidu decoction,Huashi Baidu granules,Qingfei Paidu decoction)combined with standard therapy in patients with COVID-19.Methods Randomized controlled trials of the five Chinese patent medicine or decoction combined with standard therapy were searched from EMBASE,PubMed,Cochrane Library,CNKI,WanFang database,CBM and VIP Database.The network meta-analysis were used to compare the efficacy and safety.The cost-effectiveness analysis were used to evaluate economy from Healthcare System perspective.Results A total of 11 literatures were included in this study,including 1735 patients with COVID-19.The results of network meta-analysis showed that in terms of the cough disappearance rate,total effective rate and nucleic acid negative conversion rate,Lianhua Qingwen capsules(granuless)combined with standard therapy(the following are called the"combined group")was the best.In terms of CT improvement rate and safety,Lianhua Qingwen capsule(granule)combined group ranks second in all schemes.The results of economic evaluation show that the cure costs of the Lianhua Qingwen,Jinhua Qinggan and Xuanfei Baidu combined groups were 49.42,186.90,301.00 yuan,respectively.Compared with conventional western medicine treatment group,the Lianhua Qingwen combined group costs 73.76 yuan more to make one more patient reach cough disappearance.When the willing payment value is 90 yuan,the economic probability of Lianhua Qingwen combined group was 88.8%.When the willing payment value is greater than 90 yuan,the economic probability of Lianhua Qingwen combined group is always greater than that of conventional western medicine treatment group.Conclusion Lianhua Qingwen combined group has better efficacy and safety in the treatment of COVID-19.When the willing payment value is low,conventional western medicine alone may be more economical.With the increase of willingness to pay,Lianhua Qingwen combined group may be more economical.关键词
连花清瘟胶囊(颗粒)/新型冠状病毒肺炎/经济性评价/网状Meta分析Key words
Lianhua Qingwen capsules(granules)/COVID-19/Economic evaluation/Network meta-analysis分类
医药卫生
