摘要
Abstract
Objective To explore the effects of sitagliptin combined with Zoledronic acid and metformin on bone metabolism and insulin resistance in patients with type 2 diabetes mellitus complicated with osteoporosis.Methods A total of 120 patients with type 2 diabetes mellitus combined with osteoporosis admitted to Fuxin Mine General Hospital of Liaoning Health Industry Group from March 2020 to March 2021 were selected as the study objects,and were randomly divided into observation group(61 cases)and control group(59 cases)according to envelope method.The control group was treated with metformin combined with zoledronic acid,and the observation group was treated with sitagliptin combined with zoledronic acid and metformin.The therapeutic effect,body mass index,blood glucose index,bone metabolism level and insulin resistance of the two groups before and after treatment were compared.Results The effective rate of treatment in observation group was 96.72%,which was significantly higher than that in control group(84.75%),and the difference was statistically significant(P＜0.05).Before treatment,there were no significant differences in body mass index,fasting blood glucose,glycated hemoglobin,alkaline phosphatase,osteocalcin,insulin resistance index(HOMA-IR)and islet beta cell function index(HOMA-β)between the two groups(P＞0.05).After treatment,body mass index,fasting blood glucose,glycated hemoglobin and alkaline phosphatase in both groups were lower than before treatment,and the observation group was lower than the control group,osteocalcin in both groups was higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P＜0.05);After treatment,HOMA-IR in observation group was lower than control group,HOMA-β was higher than control group,the difference was statistically significant(P＜0.05).Conclusion Sitagliptin combined with Zoledronic acid and metformin can effectively improve bone metabolism and inhibit insulin resistance in patients with type 2 diabetes mellitus combined with osteoporosis.关键词
西格列汀/唑来膦酸/二甲双胍/2型糖尿病/骨质疏松症/治疗效果/糖化血红蛋白/空腹血糖/碱性磷酸酶/骨钙素Key words
Sitagliptin/Zoledronic acid/Metformin/Type 2 diabetes combined/Osteoporosis/Treatment effect/Glycated A 1 c/Fasting blood glucose/Alkaline phosphatase/Osteocalcin分类
医药卫生
