中华神经创伤外科电子杂志2023，Vol.9Issue(6)：367-371,5.DOI:10.3877/cma.j.issn.2095-9141.2023.06.009
创伤性颅脑损伤神经生理学特征
Characteristic of neurobiology in traumatic brain injury
唐春雨 1李倩 2郭姗姗 3叶奇 4张丹5
作者信息
- 1. 300309 天津,武警特色医学中心烧伤冻伤及组织功能重建研究所
- 2. 100088 北京,火箭军特色医学中心中医科
- 3. 100088 北京,火箭军特色医学中心涉核人员治疗科
- 4. 100088 北京,火箭军特色医学中心护理部
- 5. 100088 北京,火箭军特色医学中心消化科
- 折叠
摘要
Abstract
Traumatic brain injury(TBI)endangers structural damage to the brain parenchyma,which causes death or lifelong disability in patients.Besides structural damage,the accidental injuries of the brain could cause activation of various deleterious pathways,leading to subsequent neuronal death and permanent dysfunction.The present studies show excitotoxicity,neuroinflammation,edema,oxidative stress,neuronal apoptosis and cerebral metabolic dysfunction could participate in the major pathogenic process in TBI,but few was cleared about the related molecular mechanism study.The available methods could only treated patients symptomatically,and are still not ideal for controlling secondary injuries.This article provides a review of the neurophysiological changes,neurochemical changes,and other pathological manifestations of TBI,with the aim of providing reference for TBI related research and helping clinical development of new treatment strategies to rescue the patient or reduce the occurrence of complications.关键词
创伤性颅脑损伤/兴奋性毒性/神经炎症/氧化应激/神经元凋亡Key words
Traumatic brain injury/Excitotoxicity/Neuroinflammation/Oxidative stress/Neuronal apoptosis引用本文复制引用
唐春雨,李倩,郭姗姗,叶奇,张丹..创伤性颅脑损伤神经生理学特征[J].中华神经创伤外科电子杂志,2023,9(6):367-371,5.
