摘要
Abstract
Objective To explore the effect of aspirin combined with different doses of ticagrelor on the incidence of adverse cardiovascular events in patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods A total of 220 patients who received PCI surgery in the Fifth People's Hospital of Zhangjiagang City,Suzhou from September 2020 to September 2022 were selected as the study objects,and were randomly divided into high-dose group and low-dose group by odd-even number method,with 110 cases in each group.The low-dose group was treated with aspirin combined with low-dose ticagrelor,and the high-dose group was treated with aspirin combined with high-dose ticagrelor.The cardiac function,including left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD);Microcirculation recovery,including coronary flow reserve(CFR)and microcirculation resistance index(IMR);Platelet function,including platelet maximum focusing ratio(MPAR)and P2Y12 response unit(PRU);Cardiovascular adverse events and bleeding events of the two groups were compared.Results After 3 months of treatment,LVESD and LVEDD were significantly decreased and LVEF was significantly increased in both groups,and LVESD and LVEDD were significantly lower and LVEF was significantly higher in high-dose group than those in low-dose group,the difference was statistically significant(P＜0.05).After 6 months of treatment,the levels of IMR and CFR in two groups were significantly higher than before treatment(P＜0.05),and the levels of IMR and CFR in high-dose group were significantly higher than those in low-dose group(P＜0.05).After 3 months of treatment,PRU and MPAR levels in two groups were significantly lower than before treatment(P＜0.05),and PRU and MPAR levels in high-dose group were significantly lower than those in low-dose group(P＜0.05).There was no significant difference in the incidence of adverse cardiovascular events between the two groups within 1 year of treatment(P＞0.05).The incidence of bleeding events in high-dose group was significantly higher than that in low-dose group(P＜0.05).Conclusion Aspirin combined with high-dose ticagrelor can effectively improve the cardiac function and coronary blood circulation and inhibit the platelet aggregation in patients with coronary heart disease after PCI,but it has higher risk of bleeding event than that of low-dose ticagrelor.It is necessary to select clinical dosage according to individual conditions of patients.关键词
阿司匹林/替格瑞洛/剂量/冠状动脉粥样硬化性心脏病/经皮冠状动脉介入治疗/心血管不良事件Key words
Aspirin/Ticagrelor/Dose/Coronary heart disease/Percutaneous coronary intervention/Cardiovascular adverse events分类
医药卫生
