中国药物经济学2024，Vol.19Issue(2)：107-111,5.DOI:10.12010/j.issn.1673-5846.2024.02.023
联合化疗的黄芪抗肿瘤给药时间点的筛选
Selection of Time Points of Anti-tumor Administration of Astragalus combined with Chemotherapy
摘要
Abstract
Objective To explore the optimal time of astragalus,s anti-tumor in chemotherapy of tumor.Methods According to the experimental scheme,Kunming mices were randomly divided into different groups,then were molded,administered and weighed,and tumor volume were measured.At the same time,we observed and recorded their living conditions during administering.The invasion of tumor cells were observed by HE staining,thymus and spleen were sacrificed to calculated thymus index and spleen index,the number of lymphocyte and neutrophil in the blood mice were detected by an automatic blood analyzer.Results Compared with the M group,the life quality of 5-fluorouracil(5-FU)group had no significant change,and the tumor size was significantly reduced(P<0.05).Compared with the 5-FU group,Astragalus could significantly improve the living conditions of mice and further inhibit the growth of tumors,the tumor size of mice in the 5-FU +Hm group decreased significantly(P<0.05).The tumor in group M obviously destroyed the surrounding tissue,and the surrounding tissue was rich in new blood vessels.Compared with group M,the invasion degree of tumor cells in group 5-FU and group H to the surrounding normal tissue was gradually weakened,and the new blood vessels were gradually reduced,and the obvious envelope,fewer new blood vessels and small tube diameter were formed in group H.Compared with group M,thymus index and spleen index in group 5-FU were significantly decreased(P<0.05).Compared with 5-FU group,thymus index and spleen index in H group were significantly increased(P<0.05).Compared with group M,the lymphocytes in group 5-FU were significantly decreased(P<0.05)and neutrophils were significantly increased(P<0.05).Compared with 5-FU group,the lymphocytes in H group were significantly increased(P<0.05)and neutrophils were significantly decreased(P<0.05).Conclusion Astragalus could enhance the anti-tumor effect of 5FU and improve the quality of life caused by 5-FU.The effect of Astragalus after chemotherapy was better than that of Astragalus when given at the same time.关键词
黄芪/肿瘤/给药时间Key words
Astragalus/Tumour/Administration time分类
医药卫生引用本文复制引用
邓晓霞,李清宋,李影,刘素兰..联合化疗的黄芪抗肿瘤给药时间点的筛选[J].中国药物经济学,2024,19(2):107-111,5.基金项目
2020年江西省教育厅科学技术研究项目(GJJ205607) （GJJ205607）
