转化医学杂志2023，Vol.12Issue(6)：386-395,10.DOI:10.3969/j.issn.2095-3097.2023.06.016
膀胱出口梗阻诱导膀胱纤维化分子机制及治疗策略研究进展
Research Progress on Molecular Mechanisms and Treatment Strategies of Bladder Outlet Obstruction Induced Bladder Fibrosis
摘要
Abstract
Bladder outlet obstruction(BOO)-induced bladder fibrosis can lead to irreversible functional and structural changes in the bladder,which is the end-stage change of bladder remodeling and seriously affects the quality of life of pa-tients.Mechanical stress,ischemia hypoxia,and inflammatory infiltration are important factors that initiate bladder fibrosis under long-term obstruction.On the one hand,they promote the production of extracellular matrix and collagen,while on the other hand,they inhibit their degradation and deposit a large amount on the bladder wall,resulting in a decrease in bladder wall compliance,capacity,and contraction force.At present,significant progress has been made in drug research to prevent bladder fibrosis and improve bladder function,including clinical drugs,natural Chinese herbal ingredients,polymer materials,and stem cell therapy.This review mainly summarizes the molecular mechanisms and therapeutic strategies of BOO-induced bladder fibrosis,providing certain ideas and directions for subsequent research,and also providing a theoretical basis for the development and use of related drugs.关键词
膀胱出口梗阻/膀胱疾病/纤维化/分子机制/治疗/细胞外基质/胶原/综述Key words
Bladder outlet obstruction/Bladder disease/Fibrosis/Molecular mechanism/Treatment/Extracellular matrix/Collagen/Review分类
医药卫生引用本文复制引用
汪松,陈林,何江枢,李嘉,龙军,杨进,梁国标,吴金邦,吴波..膀胱出口梗阻诱导膀胱纤维化分子机制及治疗策略研究进展[J].转化医学杂志,2023,12(6):386-395,10.基金项目
国家自然科学基金(81500577) （81500577）
四川省科技厅自然科学基金项目(2022NSFSC1592) （2022NSFSC1592）
四川省医学科研课题(S19017、S17002、Q20013、Q19022) （S19017、S17002、Q20013、Q19022）
成都大学临床医学院附属医院创新团队项目(CDFYCX202207) （CDFYCX202207）
成都市科技局重点研发支撑计划(2022YF0501441SN) （2022YF0501441SN）
