中华脑科疾病与康复杂志（电子版）2023，Vol.13Issue(6)：352-357,6.DOI:10.3877/cma.j.issn.2095-123X.2023.06.006
抽吸联合支架取栓对超时间窗后循环缺血性脑卒中患者脑血灌注的影响
Effects of aspiration combine stent for thrombectomy on cerebral blood perfusion in patients with posterior circulation ischemic stroke beyond the time window
摘要
Abstract
Objective To investigate the effects of aspiration combine stent for thrombolectomy on cerebral blood perfusion in patients with posterior circulation ischemic stroke beyond the time window.Methods A total of 97 patients with posterior circulation ischemic stroke beyond the time window who were admitted to Neurology Department of Changshu Hospital Affiliated to Xuzhou Medical University from June 2018 to June 2022 were selected as the study subjects.They were divided into drug thrombolysis group(n=48,thrombolysis with recombinant tissue plasminogen activator)and thrombectomy group(n=49,aspiration combine stent for thrombectomy)based on treatment plan.Cerebral blood perfusion,serum neuron-specific enolase(NSE)and endothelial nitric oxide synthase(eNOS)levels,adverse reactions,and prognosis were compared between two groups before and after treatment.Results After treatment,the cerebral blood volume(CBV),mean transit time(MTT),time to peak(TTP)and cerebral blood flow(CBF)of two groups significantly improved compared to before treatment,the CBV and CBF of the thrombectomy group were significantly higher than those of the drug thrombolysis group,while the MTT and TTP were significantly shorter than those of the drug thrombolysis group,and the differences were statistically significant(P＜0.05).After treatment,the serum NSE level was lower than before treatment,and the eNOS level was higher than before treatment in two groups of patients,the serum NSE level in the thrombectomy group was lower than that in the drug thrombolysis group,and the eNOS level was higher than that in the drug thrombolysis group,with statistical significance(P＜0.05).The incidence of adverse reactions in the thrombectomy group(16.33％)was lower than that in the drug thrombolysis group(35.42％),and the good prognosis rate(89.90％)was higher than that in the drug thrombolysis group(72.92％),with statistical significance(P＜0.05).Conclusion Aspiration combine stent for thrombectomy is beneficial to improve cerebral blood perfusion in patients with posterior circulation ischemic stroke beyond the time window,with significant curative effect and good safety.关键词
抽吸联合支架取栓/超时间窗/后循环缺血性脑卒中/脑血灌注Key words
Aspiration combine stent for thrombectomy/Beyond the time window/Posterior circulation ischemic stroke/Cerebral blood perfusion引用本文复制引用
李旺俊,王云霞..抽吸联合支架取栓对超时间窗后循环缺血性脑卒中患者脑血灌注的影响[J].中华脑科疾病与康复杂志（电子版）,2023,13(6):352-357,6.基金项目
Xuzhou Medical University Affiliated Hospital Development Fund Project(XYFM2021050)徐州医科大学附属医院发展基金项目(XYFM2021050) （XYFM2021050）
