中外医学研究2024，Vol.22Issue(4)：143-148,6.DOI:10.14033/j.cnki.cfmr.2024.04.036
胆红素总量/白蛋白比值、听力筛查及MRI-T1WI影像对新生儿急性胆红素脑病的诊断价值
Diagnostic Value of Total Bilirubin/Albumin Ratio,Hearing Screening and MRI-T1WI Imaging in Neonatal with Acute Bilirubin Encephalopathy
摘要
Abstract
Objective:To explore the diagnostic value of total bilirubin/albumin ratio(B/A),hearing screening and magnetic resonance image-T1-weighted imaging(MRI-T1WI)in neonatal with acute bilirubin encephalopathy(ABE).Method:A total of 136 neonatal hyperbilirubinemia(NHB)children treated in Taicang First People's Hospital from June 2013 to June 2023 were selected as the study objects,and they were divided into the concurrent group(n=42)and the control group(n=94)according to whether neonatal ABE was complicated.The clinical data,B/A levels,hearing screening results,and pallidus T1WI signal intensity of the two groups were compared.Multivariate logistic regression analysis was performed for the indicators that had significance in univariate analysis,and ROC curve was used to analyze their diagnostic value in neonatal with ABE.Result:The peak value of total serum bilirubin(TSB)and B/A level in concurrent group were higher than those in control group,the differences were statistically significant(P<0.05).The rate of hearing abnormality in the concurrent group was 38.10%at the first screening,and 35.71%at the re-screening,both higher than 18.09%and 8.51%in the control group,and the differences were statistically significant(P<0.05).The ratio of T1WI signal intensity between globus pallidus and frontal cortex(G/Gr)of the concurrent group was higher than that of the control group,and the difference was statistically significant(P<0.05).logistic regression analysis showed that B/A,hearing abnormality and G/Gr level were independent risk factors for ABE in NHB children,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the AUC values of B/A,G/Gr,hearing abnormality and their combined detection of NHB complicated ABE were 0.773,0.652,0.754 and 0.863,respectively,which had high diagnostic value,and the combined diagnosis value was the highest(P<0.05).Conclusion:The expression levels of B/A,hearing abnormality and G/Gr in children with ABE were significantly increased,and the three alone and combined detection of NHB complicated ABE in children had high diagnostic value,and the combined diagnosis effect of the three was the best.关键词
急性胆红素脑病/新生儿/胆红素总量/白蛋白比值/听力筛查/磁共振成像-T1/加权成像Key words
Acute bilirubin encephalopathy Neonate/Total bilirubin/albumin ratio/Hearing screening/Magnetic resonance image-T1-weighted imaging引用本文复制引用
王粉,王燕,顾圆,王倩倩,陈志云,田小娟..胆红素总量/白蛋白比值、听力筛查及MRI-T1WI影像对新生儿急性胆红素脑病的诊断价值[J].中外医学研究,2024,22(4):143-148,6.基金项目
2018年度苏州市"科教兴卫"青年科技项目(KJXW2018065) （KJXW2018065）
