中药材2023，Vol.46Issue(10)：2469-2474,6.DOI:10.13863/j.issn1001-4454.2023.10.016
水半夏水煎液化学成分研究
Chemical Constituents from Water Solution of Typhonium flagelliforme
摘要
Abstract
Objective:To study the chemical constituents from water solution of Typhonium flagelliforme.Methods:Medium pres-sure reversed-phase chromatography(ODS),Sephadex LH-20 dextran gel column chromatography,semi-preparative HPLC and other chromatographic methods were used to isolate and purify the water solution of Typhonium flagelliforme,the structures were identified ac-cording to physical and chemical properties,nuclear magnetic resonance spectroscopy,mass spectrometry and other data analysis.Re-sults:Twenty-five compounds were isolated from the water sdution of Typhonium flagelliforme and identified as adenosine(1),protocate-chuic acid(2),phenethylamine(3),(S)-2-hydroxy-3-(4'-hydroxyphenyl)propanoic acid(4),gentisic acid(5),L-tryptophan(6),(3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid(7),(3S,6S)-3-phenylmethyl-6-amidocarboxymethyl-piperazine-2,5-dione,cis-cyclo(Asn-Phe)(8),(-)-(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid(9),(S)-2-hydroxy-3-phenylpro-pionic acid(10),nicotinamide(11),(+)-isolariciresinol(12),pinoresinol(13),stagonoculiazin(14),1-O-hexadecanoyl-3-O-β-D-ga-lactopyranosyl-glycerol(15),linolenic acid(16),1-glyceryl linolenate(17),1-linoleoylglycerol(18),benzenetridecanoic acid(19),methyl linoleate(20),(E)-9-methyl elaidate(21),linoleic acid(22),10,13-octadecadienoic acid(23),(8-hydroxymethylen)-trieico-sanyl acetate(24),respectively.Conclusion:Among them,compounds 2 to 5,8 to 11,14,15,17,18,21,23,24 are isolated from Typho-nium flagelliforme for the first time.关键词
水半夏/化学成分/生物碱/脂肪酸Key words
Typhonium flagelliforme (Lodd. Blume)/Chemical constituents/Alkaloid/Fatty acid分类
中医学引用本文复制引用
杨甲玺,付辉政,肖小武,钟兰,赵敏敏,罗跃华..水半夏水煎液化学成分研究[J].中药材,2023,46(10):2469-2474,6.基金项目
江西省重点研发项目(20203BBG73062) （20203BBG73062）
江西省药品监督管理局科研项目(2020JS04) （2020JS04）
