中药材2023，Vol.46Issue(12)：3068-3075,8.DOI:10.13863/j.issn1001-4454.2023.12.027
基于多指标的CRITIC-AHP复合加权评分法优选厚朴-大黄药对水提工艺研究
Optimization of Water Extraction Process of Magnoliae Officinalis Cortex and Rhei Radix et Rhizoma by Multi Index Combined with CRITIC-AHP Composite Weighted Scoring Method
摘要
Abstract
Objective:To optimize the the water extraction process of Magnoliae Officinalis Cortex and Rhei Radix et Rhizoma by multi index combined with CRITIC-AHP composite weighted scoring method based on the main components.Methods:The contents of magnolol,honokiol,aloe-emodin,rhein,emodin,chrysophanol,physcion in Magnoliae Officinalis Cortex and Rhei Radix et Rhizoma were simultaneously determined by HPLC.Three scoring methods were designed with the main components of Magnoliae Officinalis Cortex,Rhei Radix et Rhizoma and Magnoliae Officinalis Cortex with Rhei Radix et Rhizoma as the indexes.The CRITIC-AHP composite weighting method was used to calculate the index weight coefficient of each score,and the comprehensive score was carried out.Com-bined with the L9(34)orthogonal table,the effects of liquid material ratio,decocting time and decocting times on the water extraction process of Magnoliae Officinalis Cortex and Rhei Radix et Rhizoma were investigated,and the best water extraction process was opti-mized.Results:The best technology of the three scoring methods of Magnoliae Officinalis Cortex and Rhei Radix et Rhizoma for water extraction process was to take 30 times of the prescription,decoct for 30 min,decoct for 3 times.Conclusion:The water extraction process of Magnoliae Officinalis Cortex and Rhei Radix et Rhizoma is optimized by CRITIC-AHP composite weighting method and or-thogonal table.The extraction process is stable and feasible,which provides a reference for the modern extraction research of the drug pair and the development of compound preparations.关键词
厚朴/大黄/多指标测定/CRITIC-AHP法/正交设计Key words
Magnoliae Officinalis Cortex/Rhei Radix et Rhizoma/Multi index determination/CRITIC-AHP method/Orthogonal design分类
医药卫生引用本文复制引用
刘畅,邓鸿丹,杨璐萍,张芮苑,刘芳,任虹..基于多指标的CRITIC-AHP复合加权评分法优选厚朴-大黄药对水提工艺研究[J].中药材,2023,46(12):3068-3075,8.基金项目
国家自然科学基金项目青年基金项目(81603300) （81603300）
中国博士后科学基金面上项目"西部地区博士后人才资助计划"(2020M673569XB) （2020M673569XB）
四川省科技厅项目(2020YJ0370) （2020YJ0370）
成都市科技局项目(2022-YF05-01112-SN) （2022-YF05-01112-SN）
