中药材2023，Vol.46Issue(9)：2224-2232,9.DOI:10.13863/j.issn1001-4454.2023.09.021
基于ICP-MS的不同产地丹参元素差异分析及健康风险评估
Element Difference Analysis and Health Risk Assessment of Salviae Miltiorrhizae Radix et Rhizoma from Different Producing Areas Based on ICP-MS
摘要
Abstract
Objective:To study the distribution differences of 40 inorganic elements in Salviae Miltiorrhizae Radix et Rhizoma from different producing areas,and to evaluate the health risks of heavy metals and harmful elements.Methods:467 samples of 31 batches from 5 major producing areas of Salviae Miltiorrhizae Radix et Rhizoma were collected,and the contents of inorganic elements were de-termined by ICP-MS method.The origin identification analysis and different elements screening were carried out by stoichiometric meth-od.The safety evaluation was carried out by calculating the single pollution index and Nemerow comprehensive pollution index of heavy metals and harmful elements.Health risks were assessed based on maximum tolerable daily intake and cancer risk.Results:The content of rare earth elements La and Ce in Salviae Miltiorrhizae Radix et Rhizoma from Sichuan was the highest,the content of inorganic ele-ments Na,Sr,Nb and Cu in Salviae Miltiorrhizae Radix et Rhizoma from Shandong was the highest,and the content of other elements in Salviae Miltiorrhizae Radix et Rhizoma from Henan and Shaanxi was relatively high.There were significant differences in the content of inorganic elements of Salviae Miltiorrhizae Radix et Rhizoma from different habitats.The linear discriminant analysis model had the best discriminant effect on the origin of Salviae Miltiorrhizae Radix et Rhizoma,and the accuracy of its training set and prediction set both reached more than 90%.Safety evaluation showed that most samples were in safe state.The results of the health risk assessment model showed that there was no obvious health risk from the use of Salviae Miltiorrhizae Radix et Rhizoma,but the carcinogenic health risk caused by As exposure in individual bases should be paid attention to.Conclusion:The distribution of inorganic elements of Salviae Milt-iorrhizae Radix et Rhizoma from different habitats has characteristic characteristics.The content of heavy metals in Salviae Miltiorrhizae Radix et Rhizoma is at the safe level and has no obvious health risk.This study provides a reference for the establishment of traceability detection system,health risk assessment and quality evaluation system of Salviae Miltiorrhizae Radix et Rhizoma.关键词
丹参/ICP-MS/化学计量学/无机元素/健康风险评估Key words
Salviae Miltiorrhizae Radix et Rhizoma/ICP-MS/Chemometrics/Inorganic element/Health risk assessment分类
医药卫生引用本文复制引用
王巧,于永杰,王紫怡,杨程远,周利,郝庆秀,杨健,黄璐琦..基于ICP-MS的不同产地丹参元素差异分析及健康风险评估[J].中药材,2023,46(9):2224-2232,9.基金项目
山东省重点研发计划(重大科技创新工程)项目(2021CXGC010508) （重大科技创新工程）
国家产业技术基础公共服务平台项目(2022-230-221) （2022-230-221）
中国中医科学院科技创新工程项目(CI2021A04005) （CI2021A04005）
