中药材2023，Vol.46Issue(11)：2799-2804,6.DOI:10.13863/j.issn1001-4454.2023.11.028
基于传质模型探索乙醇溶液环境中黄连生物碱的纳滤分离机制
Exploring the Nanofiltration Mechanism of Coptidis Rhizoma Alkaloids in Ethanol Solution by Mass Transfer Model
摘要
Abstract
Objective:To explore the mechanism of nanofiltration separation of Coptidis Rhizoma alkaloids in ethanol solution based on mass transfer model.Methods:Using a nanofiltration mass transfer model combined with Box-Behnken design,the nanofiltration sepa-ration rule of resin eluents of Coptidis Rhizoma alkaloids was summarized to analyze the separation mechanism of three alkaloids in eth-anol solution.Results:The experiment showed that the nanofiltration separation mathematical model was valid,which could be used to investigate the internal relationship between factors and component separation behavior.The ethanol concentration had significant effect on the rejection of berberine hydrahloride,palmatine hydrahloride and coptidine hydrahloride,which correlated with the oil-water parti-tion coefficient of solutes.By fitting the power function equation and analyzing the sensitivity coefficients of solute rejection to the inves-tigated factors,the sensitivity coefficients of the three alkaloids to the molecular weight cut-off of nanofiltration were all greater than 50,and the sensitivity coefficients of pH were all greater than 30.The molecular sieving and charge effect were dominant in nanofiltration separation.The mass transfer coefficient of Coptidis Rhizoma alkaloids decreased with the extension of ethanol concentration,and the sensitivity coefficient of Coptidis Rhizoma alkaloids to ethanol concentration was palmatine hydrahloride>berberine hydrahloride>cop-tidine hydrahloride.Conclusion:According to the difference of the power function curves between mass transfer coefficients and ethanol concentration,it provides the theoretical support for the orderly separation of multiple components in the complex solution system of Chi-nese medicine.关键词
黄连生物碱/乙醇/纳滤/传质模型/敏感系数Key words
Coptidis Rhizoma alkaloids/Ethanol/Nanofiltration/Mass transfer model/Sensitivity coefficient分类
医药卫生引用本文复制引用
章莲,徐扬阳,李存玉,刘安蓉,支兴蕾,周余庆..基于传质模型探索乙醇溶液环境中黄连生物碱的纳滤分离机制[J].中药材,2023,46(11):2799-2804,6.基金项目
国家自然科学基金资助项目(82274106,82074006) （82274106,82074006）
江苏省自然科学基金资助项目(BK20211303) （BK20211303）
大学生创新创业训练计划资助项目(202310315046Z) （202310315046Z）
