基于"炎癌转化"理论探讨中医药治疗慢性萎缩性胃炎的机制OA
Study on The Mechanism of Treating Chronic Atrophic Gastritis with Traditional Chinese Medicine Based on the Theory of"Inflammation and Cancer Transformation"
慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)是以胃黏膜固有腺体减少、萎缩为基本特征的一种慢性胃部疾病.长期慢性的非可控炎症使得胃黏膜长时间处于高炎性反应状态,或可诱导胃恶性肿瘤的发生,该过程为胃"炎癌转化".目前中医药治疗CAG临床疗效确切,能有效延缓甚至逆转胃"炎癌转化",本文从中医药改善胃黏膜萎缩和改善肿瘤形成前微环境两方面来探讨其治疗CAG的机制,以期为中医药治疗CAG、干预"炎癌转化"、逆转癌前病变提供证据支持及治疗思路.
Chronic atrophic gastritis(CAG)is a chronic gastric disease characterized by the reduction and atrophy of the inherent glands of the gas-tric mucosa.However,long-term non-controllable inflammation makes the gastric mucosa in a state of high inflammatory response for a long time,which can induce the occurrence of gastric malignant tumors.This process is called the"inflammatory cancer transformation"of the stomach.At present,the clinical efficacy of traditional Chinese medicine in the treatment of CAG is certain,which can effectively delay or even reverse the"in-flammatory cancer transformation".But the mechanism is more complex,so this article elaborates on the research progress of the mechanism of ac-tion of traditional Chinese medicine in the treatment of CAG to provide evidence support and new treatment ideas for the treatment of CAG,the inter-vention of"inflammatory cancer transformation",and the reversal of precancerous lesions by traditional Chinese medicine.
徐璐;王渝涵;李非凡;阳正国
重庆医科大学附属永川中医院,重庆 402160||重庆市永川中医院/重庆市名老中医阳正国传承工作室,重庆 402160成都中医药大学针灸推拿学院,四川成都 610075重庆医科大学附属永川中医院,重庆 402160
中医学
慢性萎缩性胃炎中医药炎癌转化
chronic atrophic gastritistraditional Chinese medicineinflammatory cancer transformation
《中医康复》 2024 (004)
39-43 / 5
重庆市永川区自然科学基金项目(2022yc-jckx20046):蒲藤护胃汤治疗慢性萎缩性胃炎的临床研究,负责人:阳正国.
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