赣南医学院学报2024，Vol.44Issue(1)：92-98,104,8.DOI:10.3969/j.issn.1001-5779.2024.01.015
脐带间充质干细胞治疗椎间盘退变研究进展
Research progress in the treatment of intervertebral disc degeneration with umbilical cord mesenchymal stem cells
摘要
Abstract
In recent years,the number of patients with low back pain is increasing and the morbidity age assumes the youth-oriented.It has been found that one of the important causes of low back pain is intervertebral disc degeneration.Umbilical cord mesenchymal stem cells(UCMSCs)are widely used in tissue repair and regeneration research because of their self-renewal ability,multidirectional differentiation potential,homing,and immunomodulatory properties.UCMSCs can differentiate into myeloid cells after transplantation into intervertebral discs,synthesize and secrete extracellular matrix components of the nucleus pulposus such as proteoglycan and type Ⅱ collagen,or secrete immunomodulatory factors to repair disc degeneration,and are one of the potential cells for nucleus pulposus degeneration and repair.It is one of the potential cells for medullary degeneration and repair.This paper reviews the research progress of UCMSCs in the treatment of intervertebral disc degeneration,with the aim of providing a reference for subsequent relevant clinical studies.关键词
脐带间充质干细胞/椎间盘退变/外泌体/修复再生Key words
Umbilical cord mesenchymal stem cells/Intervertebral disc degeneration/Exosome/Repair and regenerate分类
临床医学引用本文复制引用
张学良,冉兵,钟瑞丹,叶军明..脐带间充质干细胞治疗椎间盘退变研究进展[J].赣南医学院学报,2024,44(1):92-98,104,8.基金项目
赣南医学院研究生创新专项资金项目(YC2022-X008) （YC2022-X008）
