赣南医学院学报2024，Vol.44Issue(1)：99-104,6.DOI:10.3969/j.issn.1001-5779.2024.01.016
纳米孔基因测序技术在HLA基因分型中的应用
Application of nanopore sequencing technology in HLA typing
摘要
Abstract
The human leukocyte antigen(HLA)gene is the most complex regions of the human genome,which mainly participates in the immune response of the body.HLA typing has extensive clinical applications in organ transplantation,disease diagnosis and treatment,and other related fields.The existing methods for HLA typing have played a crucial role in clinical practice,but they do have certain technical limitations.However,the advent of nanopore sequencing technol-ogy has offered a fresh perspective for the rapid identification of HLA typing.This technology,with its fast and real-time sequencing capabilities,as well as its long read length characteristics,facilitates faster and more accurate recognition of complex HLA regions.It not only enables quicker analysis of HLA genotypes,but also has the potential to serve as a ref-erence for the development of cutting-edge high-throughput gene sequencing methods for HLA typing.This article mainly reviews the research methods and clinical applications of nanopore gene sequencing technology in the field of HLA typing.关键词
人类白细胞抗原/基因分型技术/纳米孔基因测序/器官移植Key words
Human leukocyte antigen/Genotyping techniques/Nanopore sequencing/Organ transplantation分类
医药卫生引用本文复制引用
朱孟琳,何燕琴,谢水莲,杨影,万绍贵..纳米孔基因测序技术在HLA基因分型中的应用[J].赣南医学院学报,2024,44(1):99-104,6.基金项目
赣南医学院校级课题(YC2022-X012) （YC2022-X012）
