解放军医学杂志2024，Vol.49Issue(2)：229-235,7.DOI:10.11855/j.issn.0577-7402.0151.2023.0531
粪菌移植在难治性腹泻中的应用进展
Application and research progress of fecal microbiota transplantation in refractory diarrhea
摘要
Abstract
When refractory diarrhea comes on,it greatly affects the life and daily work of patients,and there is no unified treatment.Patients with refractory diarrhea have varying degrees of intestinal flora disorder,so rebuilding the intestinal micro ecosystem may be an effective way to treat refractory diarrhea.Fecal microbiota transplantation(FMT)has the potential to be an effective treatment for refractory diarrhea as a therapy that reconstructs normal intestinal flora.In recent years,FMT has been applied to the treatment of some refractory diarrhea related to intestinal flora imbalance,such as recurrent clostridium difficile infection,inflammatory bowel disease,irritable bowel syndrome,and has achieved good results,but some problems have not been properly solved so far.This article reviews the mechanism of action of FMT in the treatment of refractory diarrhea,its clinical application,research progress and current problems.关键词
粪菌移植/肠道菌群/难治性腹泻Key words
fecal microbiota transplantation/intestinal flora/refractory diarrhea分类
医药卫生引用本文复制引用
李彤,王宁,王新..粪菌移植在难治性腹泻中的应用进展[J].解放军医学杂志,2024,49(2):229-235,7.基金项目
This work was supported by the IIT Clinical Research Program of the Second Affiliated Hospital of Air Force Military Medical University(2022XJSXYW-007) 空军军医大学第二附属医院IIT临床研究项目(2022XJSXYW-007) （2022XJSXYW-007）
