激光生物学报2024，Vol.33Issue(1)：1-13,13.DOI:10.3969/j.issn.1007-7146.2024.01.001
面向阿尔茨海默病的非侵入性光生物调节治疗
Non-invasive Photobiomodulation Therapy for Alzheimer's Disease
摘要
Abstract
According to the official website of the Alzheimer's Disease Association of China,there are about 15 million de-mentia patients in the elderly aged 60 and over in China,of which 10 million are Alzheimer's patients.With the aging of China's structural population,this data will continue to rise.At present,according to the logic of modern medicine to find therapeutic targets,there is no effective treatment for Alzheimer's disease.There are many limitations in drug treatment,and surgery is pow-erless.In this regard,we have to rethink the traditional systematic,holistic and functional point of view,and take corresponding treatment strategies for the leading factors behind Alzheimer's disease.In recent years,research on photobiomodulation(PBM)in the treatment of neurodegenerative diseases has gradually increased.More and more scholars have tried to use non-invasive PBM to delay,inhibit,and even reverse neurodegenerative diseases.In the treatment of neurological diseases,PBM,as a new treatment method,has significant advantages such as non-invasive,no side effects,regulation of oxygen free radical concentra-tion,activation of stem cells to regulate cell transcription,stimulation of neurotransmitter secretion,and stimulation of synapse and neuron growth.These advantages are unmatched by other treatments.This paper reviews the targets of modern medicine for the treatment of Alzheimer's disease,explains the mechanism of PBM in the treatment of Alzheimer's disease,and systemati-cally summarizes the progress of PBM in the treatment of Alzheimer's disease from animal models,clinical trials,pathology and cell models,and looks forward to the future development,aiming to provide reference for exploring new clinical intervention measures for Alzheimer's disease and developing advanced treatment methods and medical devices.关键词
光生物调节/阿尔茨海默病/近红外光/先进治疗方法/医疗器械Key words
photobiomodulation/Alzheimer's disease/near-infrared light/advanced therapy methods/medical device分类
医药卫生引用本文复制引用
魏双红,刘琦,郭延光,张玉琴,王韵乐,霍星星,陈雷..面向阿尔茨海默病的非侵入性光生物调节治疗[J].激光生物学报,2024,33(1):1-13,13.基金项目
国家自然科学基金项目(21875058) （21875058）
安徽省杰出青年基金项目(2208085J13) （2208085J13）
合肥工业大学智能制造技术研究院科技成果培育专项项目(IMIPY2021025) （IMIPY2021025）
安徽省科技重大专项项目(202103a05020025) （202103a05020025）
2022年度中山市重大科技专项战略性新兴产业技术攻关专题项目(2022A1007). （2022A1007）
