日粮添加表皮生长因子对断奶仔猪肠道抗氧化能力、炎症反应和免疫状态的影响OACSTPCD

Epidermal growth factor(EGF)is a cytoprotective peptide that plays a crucial role in gut growth and health.The study mainly explored the effects of EGF on the intestinal antioxidant capacity,inflammatory response,immune status in wean-ing piglets.Forty-two 21-day-old weaned piglets were randomly assigned to three treatments consisting of a same basic diet containing 0(control),200,or 400 µg/kg EGF,respectively.There were 14 replicates per treatment,and 7 piglets per treatment were sampled on days 7 and 14 of the experiment.Dietary supplementation of 200 µg/kg EGF increased the activity of super-oxide dismutase(SOD)during the entire experimental period.This supplementation decreased malondialdehyde(MDA)content whereas it increased serum immunoglobulin A(IgA)content on day 7 post-weaning.Animals receiving the diet supplemented with 400 µg/kg EGF decreased concentration of tumor necrosis factor-α(TNF-α)and tended to increase the level of secretory immunoglobulin A(SIgA)in the overall experimental period.In addition,the phosphorylation level of nuclear factor-κB(NF-κB)p65 was higher for piglets fed EGF diet.In summary,EGF can enhance intestinal antioxidant capacity,decrease inflammatory response,and increase immune status in weaned piglets,suggesting that EGF has a positive role in piglet gut health.