激光生物学报2024，Vol.33Issue(1)：57-64,8.DOI:10.3969/j.issn.1007-7146.2024.01.007
日粮添加表皮生长因子对断奶仔猪肠道抗氧化能力、炎症反应和免疫状态的影响
Effects of Dietary Supplementation with Epidermal Growth Factor on Intestinal Antioxidant Capacity,Inflammatory Response,and Immune Status in Weaning Piglets
摘要
Abstract
Epidermal growth factor(EGF)is a cytoprotective peptide that plays a crucial role in gut growth and health.The study mainly explored the effects of EGF on the intestinal antioxidant capacity,inflammatory response,immune status in wean-ing piglets.Forty-two 21-day-old weaned piglets were randomly assigned to three treatments consisting of a same basic diet containing 0(control),200,or 400 µg/kg EGF,respectively.There were 14 replicates per treatment,and 7 piglets per treatment were sampled on days 7 and 14 of the experiment.Dietary supplementation of 200 µg/kg EGF increased the activity of super-oxide dismutase(SOD)during the entire experimental period.This supplementation decreased malondialdehyde(MDA)content whereas it increased serum immunoglobulin A(IgA)content on day 7 post-weaning.Animals receiving the diet supplemented with 400 µg/kg EGF decreased concentration of tumor necrosis factor-α(TNF-α)and tended to increase the level of secretory immunoglobulin A(SIgA)in the overall experimental period.In addition,the phosphorylation level of nuclear factor-κB(NF-κB)p65 was higher for piglets fed EGF diet.In summary,EGF can enhance intestinal antioxidant capacity,decrease inflammatory response,and increase immune status in weaned piglets,suggesting that EGF has a positive role in piglet gut health.关键词
表皮生长因子/抗氧化能力/免疫力/炎症/断奶仔猪Key words
epidermal growth factor(EGF)/antioxidant capacity/immunity/inflammation/weaning piglets分类
畜牧业引用本文复制引用
王茜茜,王丽霞,刘东,李雅丽,李建中,杨焕胜..日粮添加表皮生长因子对断奶仔猪肠道抗氧化能力、炎症反应和免疫状态的影响[J].激光生物学报,2024,33(1):57-64,8.基金项目
国家自然科学基金重点项目(32130099) （32130099）
湖南省自然科学基金项目(2020JJ5635) （2020JJ5635）
湖南省科技创新平台与人才计划项目(2022RC3060).Key Project of National Natural Science Foundation of China(32130099) （2022RC3060）
Hunan Provincial Natural Science Foundation(2020JJ5635) （2020JJ5635）
Hunan Provincial Science and Technology Innovation Platform and Talent Project(2022RC3060). （2022RC3060）
