基础医学与临床2024，Vol.44Issue(3)：303-307,5.DOI:10.16352/j.issn.1001-6325.2024.03.0303
PIK3CA突变与乳腺癌临床病理特征及预后的相关性
Correlation between PIK3CA mutation and clinicopathological features and prognosis of breast cancer
摘要
Abstract
Objective To find the correlation between phosphatidylinositol kinase-3 catalytic subunit A gene(PIK3CA)mutation and pathological features as well as clinical prognosis of breast cancer.Methods The patho-logical data of 181 patients diagnosed with invasive breast cancer from January 2018 to January 2020 were collected.The estrogen receptor(ER),progestogen receptor(PR),human epidermal growth factor receptor-2(HER2),Ki67 were examined by immuno-histochemistry(IHC).Mutation of exon 9 and exon 20 of PIK3CA were examined by quantitative real-time PCR(qPCR).Results Among 181 cases of invasive breast cancer,70 cases had PIK3CA mutation with 31 cases(44.28%)showed exon 9 mutations and 39 cases(55.71%)showed exon 20 mutations.The difference between PIK3CA mutation and their distribution in molecular typing of breast cancer was statistically significant(P＜0.05).The expression of PIK3CA mutation in breast cancer with different Ki67 expression was sig-nificantly different(P＜0.05).There were 34 cases(48.57%)showed PIK3CA mutations in the HR+/HER2 group and 36 cases(51.43%)of non HR+/HER2 group mutations.There was a statistically significant difference in the distribution of PIK3CA mutations between 2 groups(P＜0.05).The death rate of PIK3CA mutation cases was higher than that of PIK3CA wild type cases(P＜0.05).Conclusions PIK3CA mutation is associated with molecular typ-ing,Ki67 increment index and prognosis of breast cancer.Detection of PIK3CA mutation provides potential support to the development of precise treatment of breast cancer patients.关键词
乳腺癌/磷脂酰肌醇激酶-3-催化亚基α(PIK3CA)/雌激素受体/孕激素受体/人表皮生长因子受体2Key words
breast cancer/phosphatidylinositol kinase-3-catalytic subunit(PIK3CA)/estrogen receptor/progestogen receptor/hu-man epidermal growth factor receptor 2分类
医药卫生引用本文复制引用
依合里曼·买买提,曹燕珍,王翠翠,岳娜,梁莉萍..PIK3CA突变与乳腺癌临床病理特征及预后的相关性[J].基础医学与临床,2024,44(3):303-307,5.基金项目
新疆自治区自然科学基金(2020D01C201) （2020D01C201）
