杭州师范大学学报（自然科学版）2024，Vol.23Issue(2)：113-123,11.DOI:10.19926/j.cnki.issn.1674-232X.2023.05.251
基于玉米醇溶蛋白-透明质酸载体的结肠靶向口服纳米药物研究
Study on Colon-targeted Oral Nanomedicine Based on Zein-HA Carrier
摘要
Abstract
Oral nanocarriers for colon-targeted medicine delivery based on Zein-hyaluronic acid(HA)were designed in this study.The nanomedicine of Zein-HA-hydroxycamptothecin(Zein-HA@HCPT)was prepared by the ultrasound dialysis method.The preparation conditions of the nanomedicine were optimized by desirability function.The microstructure,drug release behavior,cytotoxicity and targeted cellular uptake ability of the nanomedicine were investigated.The results showed that Zein-HA@HCPT possessed a high drug encapsulation efficiency over 95％.Meantime,it exhibited excellent biological stability,biocompatibility,and unique gastric acid resistance.The cumulative release of drugs in the colonic environment was significantly improved.Furthermore,Zein-HA@HCPT was targeted and taken up by colon cancer cells through CD44 receptor mediated endocytosis,which can improve the anti-tumor efficacy of drugs.关键词
玉米醇溶蛋白/透明质酸/羟基喜树碱/结肠靶向Key words
Zein/hyaluronic acid/hydroxycamptothecin/colon-targeted分类
化学化工引用本文复制引用
朱曙霞,王美玲,许紫宁,庾远龙,潘建林,汪红娣..基于玉米醇溶蛋白-透明质酸载体的结肠靶向口服纳米药物研究[J].杭州师范大学学报（自然科学版）,2024,23(2):113-123,11.基金项目
浙江省自然科学基金项目(LQ20B060003) （LQ20B060003）
杭州师范大学科研启动经费项目(2018QDL040). （2018QDL040）
