基础医学与临床2024,Vol.44Issue(3):389-392,4.DOI:10.16352/j.issn.1001-6325.2024.03.0389
P2X7受体在癌痛中作用的研究进展
Research progress on P2X7 receptor in cancer pain
摘要
Abstract
The activation of the P2X7 receptor as an ATP-gated ion channel,triggers the release of pro-inflammato-ry cytokines in tumor carring individuals and stimulate excitation of injury-causing neurons,thereby exacerbating the transmission of pain.In preclinical cancer pain models,it has the potential to serve as a new therapeutic target for cancer pain management.关键词
P2X7受体/癌痛/神经胶质细胞/P2X7拮抗剂Key words
P2X7 receptor/cancer pain/glial cell/P2X7 antagonist分类
医药卫生引用本文复制引用
张忠文,赵瑞,张浩龙,杨钰婷,白金霞,张浩令,王薇..P2X7受体在癌痛中作用的研究进展[J].基础医学与临床,2024,44(3):389-392,4.基金项目
甘肃省自然科学基金(22JR5RA582,21JR1RA267) (22JR5RA582,21JR1RA267)
甘肃省高等学校创新基金(2023A-088) (2023A-088)
甘肃省中医药研究中心专项开放课题(zyzx-2020-zx10) (zyzx-2020-zx10)
甘肃省教育科技创新项目(2022A-067) (2022A-067)