昆明医科大学学报2024，Vol.45Issue(2)：65-76,12.DOI:10.12259/j.issn.2095-610X.S20240209
益生菌辅助治疗骨质疏松患者效果的Meta分析
A Meta-analysis of the Effect of Adjuvant Probiotics in Patients with Osteoporosis
摘要
Abstract
Objective Systematically evaluate the efficacy of probiotics in treating osteoporosis.Methods Computer search of Cochrane Library,Web of Science,PubMed,Embase,VIP,CNT and Wanfang data knowledge service platform,the search time limit of August 15,2023,included as a randomized controlled experiment of probiotics for the treatment of osteoporosis.Two researchers independently screened the literature,extracted the data,and evaluated the risk of bias in the included literature.The effects of probiotic treatment on BMD,blood calcium,vitamin D,parathyroid hormone,osteocalcin,bone alkaline phosphatase and adverse reactions were analyzed by using Stata A.14 and Revman.5.4 software.Results Eight articles were finally included,Including 744 study subjects,The results of the Meta-analysis showed that,Add probiotics to traditional drug therapy,Can increase hip bone mineral density in patients[WMD 0.05(0.01,0.10)]g/cm3,Increase the calcium ion concentration in the patient's blood[WMD 0.26(0.02,0.50)]mmol/L mmol/L,Increase the concentration of blood osteocalcin[WMD 1.84(0.60,3.07)]ng/mL,Lower the bone-specific alkaline phosphatase concentration[SMD-1.06(-2.06,-0.07)],And reduce the incidence of nausea and diarrhea,However,there was no significant change in vitamin D and parathyroid hormone.Conclusion The addition of probiotics on the basis of routine treatment may improve the level of bone mineral density and reduce the adverse reactions of gastrointestinal tract,which is beneficial to the prognosis of patients.关键词
益生菌/骨质疏松/骨质疏松症/Meta分析Key words
Probiotics/Osteoporosis/Osteoporoses/Meta analysis分类
医药卫生引用本文复制引用
冉蕾晶,王绍华,李林童,桂莉..益生菌辅助治疗骨质疏松患者效果的Meta分析[J].昆明医科大学学报,2024,45(2):65-76,12.基金项目
国家自然科学基金资助项目(82160175) （82160175）
云南省"高层次人才培养支持计划"名医专项计划(YNWRMY2020010) （YNWRMY2020010）
云南省第三人民医院院内科学研究计划项目(2022SSYKT005) （2022SSYKT005）
