皮肤性病诊疗学杂志2024，Vol.31Issue(2)：67-76,10.DOI:10.3969/j.issn.1674-8468.2024.02.001
含青蒿挥发油的护肤品在敏感性皮肤人群中的效果及安全性
Clinical observation on the efficacy and safety of skin care product containing artemisia naphtha in individuals with sensitive skin
摘要
Abstract
Objective To evaluate the safety and efficacy of skin care product containing arte-misia naphtha in individuals with sensitive skin.Methods A single-center and self-controlled(before and after application)clinical trial was conducted in 31 subjects with sensitive skin.Test product was applied to the face of the subjects twice daily for 4 weeks.Measurement of physiologi-cal function,VISIA-CR photography and lactic acid test were carried out on the skin before and on the days 7,14,28 of the trial.16S rRNA gene sequencing technology was used to analyze the mi-croecological diversity of the skin surface meanwhile physician and subject'self-assessments were performed.Results Physician assessment scores for erythema were decreased at all three follow-up visits(P＜0.05 vs.baseline).The subjects'self-assessments of itching,tingling,burning,tightness,flushing and sensitivity scores were also decreased(all P＜0.05 vs.baseline).The skin a*values were decreased significantly(all P＜0.05 vs.baseline).Similarly,erythema in-dex was significantly decreased(all P＜0.05 vs.baseline).Moreover,stratum corneum hydra-tion levels were significantly increased on D7 and D28(all P＜0.05 vs.baseline).The transepi-dermal water loss rates tended to decrease,and were significantly different between the baseline and day 14(P＜0.05).In contrast,the skin elasticity and firmness parameters were not changed significantly.Furthermore,lactic acid scores were decreased significantly on D14 and D28(all P＜0.001 vs.baseline).Additionally,there was a tendency of increases in alpha diversity indices ACE and Chaol on days D7 and D14,with a significant increase on day 14(P＜0.05 vs.base-line).Beta diversity analysis showed that the four groups of samples failed to gather into clusters,and the differences in composition structure were not significant.No adverse reactions were ob-served during the trial.Conclusions Skin care product containing artemisia naphtha is safe for individuals with sensitive skin and improves multiple clinical signs and symptoms of sensitive skin,including acceleration of the skin barrier recovery,elevation in stratum corneum hydration,reduc-tion in transepidermal water loss rates and lactate stinging test score,alleviation of itching,ting-ling,burning,tightness and flushing,and increases in the richness and diversity of facial skin microbiota.关键词
敏感性皮肤/青蒿挥发油/护肤品/安全性/功效性/微生态Key words
sensitive skin/artemisia naphtha/skin care/safety/efficacy/microecol-ogy引用本文复制引用
王莎,李佳佳,李玲,敖瑜灿,杨宇阁,黄虎,刁庆春,陶侃,吕静,江阳,郭莉莉,秦紫嫣,葛梦茹..含青蒿挥发油的护肤品在敏感性皮肤人群中的效果及安全性[J].皮肤性病诊疗学杂志,2024,31(2):67-76,10.基金项目
重庆市药品不良反应监测中心科研项目(H0120230001) （H0120230001）
