摘要
Abstract
Objective To explore the clinical significance of platelet-related parameters in children with chronic spontaneous urticaria(CSU).Methods Sixty-eight children with CSU and 68 children without CSU were enrolled.The differences in platelet-related parameters,including platelet count(PLT),mean platelet volume(MPV),and platelet distribution width(PDW),were compared between the two groups.The association of the disease course and disease severity with platelet-related parameters were analyzed in CSU children.Results PLT levels were signifi-cantly higher in children with CSU than in that without CSU(t=3.96,P＜0.001).In contrast,children with CSU had significantly lower MPV(t=-5.99,P＜0.001)and PDW(t=-8.12,P＜0.001)than children without CSU.Moreover,severity of disease did not correlated with PLT,MPV and PDW(P＞0.05).However,the disease course correlated positively with MPV(r=0.26,P=0.034)and PDW(r=0.35,P=0.004),but not with PLT levels(r=0.02,P=0.875),in children with CSU.PLT levels negatively correlated with MPV(r=-0.41,P＜0.05)and PDW(r=-0.34,P＜0.05).Conclusions Platelet-related parameters can reflect the occurrence and development of CSU in children.MPV and PDW can serve as indicators to e-valuate platelet activation and predictors of the course of CSU in children.关键词
慢性自发性荨麻疹/儿童/血小板计数/平均血小板体积/血小板分布宽度Key words
chronic spontaneous urticaria/children/platelet count/mean platelet vol-ume/width of platelet distribution
