自噬与恶性黑色素瘤侵袭转移相关性研究进展OA
Research progress on the association of autophagy with invasion and metastasis of malig-nant melanoma
自噬是真核细胞特有的一种生命现象,对于促进细胞的生存,积极适应不同环境有十分重要的作用.自噬在肿瘤发生和转移的过程中起着双刃剑的作用.在黑素细胞肿瘤中关于自噬的研究结果大不相同,其原因可能与黑素细胞肿瘤的内在异质性以及使用不同的自噬检测技术有关,不同角度的研究均支持自噬与恶性黑素瘤之间存在着密切的相互作用,特别是自噬在药物靶向治疗中的作用更为重要.本文拟综述自噬在黑色素瘤侵袭、转移等生物学过程中的双重作用,为开发恶性黑色素瘤新的治疗方案及发现新的生物标志物提供线索.
Autophagy is a unique biological phenomenon of eukaryotic cells.Autophagy plays a very important role in promoting the survival of cells and actively adapting to different environ-ments.Autophagy plays a double-edged role in the development of tumor and metastasis.The re-search results on the link between autophagy and melanoma are inconsistent,likely due to the in-trinsic heterogeneity of melanoma and the difference in methodology of detecting autophagy.How-ever,the results of studies on different aspects support a link between autophagy and malignant melanoma,especially the important role of autophagy in targeted drug therapy.This paper reviews the dual role of autophagy in the biological processes of melanoma invasion and metastasis,in or-der to provide clues for the development of new therapeutic regimens and biomarkers for malignant melanoma.
高翔;赵雪宁;韩昭
成安县人民医院永年区第一医院河北工程大学附属医院,河北 邯郸 056000
自噬肿瘤黑色素瘤
autophagytumormelanoma
《皮肤性病诊疗学杂志》 2024 (2)
118-122,5
河北省卫生健康委科研基金项目(20220664)
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