中国组织工程研究2024，Vol.28Issue(29)：4599-4604,6.DOI:10.12307/2024.570
抗生素骨水泥增强胫骨横向骨搬运治疗感染创面的能力
Antibiotic-loaded bone cement enhances ability of tibial cortex transverse transport for treating infected wounds
刘俊鹏 1要星晨 1赵会 1徐子彧 1吴岳 1裴福春 2张林 2杜心如1
作者信息
- 1. 首都医科大学附属北京朝阳医院骨科,北京市 100027
- 2. 北京朝阳中西医结合急诊抢救医院,北京市 100022
- 折叠
摘要
Abstract
BACKGROUND:Diabetic foot patients with wound infections constitute a large patient population,and there is currently no satisfactory treatment approach.
OBJECTIVE:To investigate the clinical efficacy of a modified tibial cortex transverse transport combined with antibiotic-loaded bone cement for treating refractory diabetic foot ulcers.
METHODS:A total of 46 diabetic foot ulcers patients,27 males and 19 females,with an average age of 64.37 years,were selected from Beijing Chaoyang Hospital,Capital Medical University and Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital from January 2020 to January 2023.All of them underwent the modified tibial cortex transverse transport combined with antibiotic-loaded bone cement treatment.Ankle-brachial index,WIFi(Wound/Ischemia/Foot infection)classification,pain visual analog scale score,and ulcer area were recorded before and 3 months after surgery.
RESULTS AND CONCLUSION:(1)The mean ulcer healing time for the 46 patients was(58.07±24.82)days.At 3 months postoperatively,there were significant improvements in ankle-brachial index,pain visual analog scale score,ulcer area,and WIFi classification in 46 patients,as compared to the preoperative values,with statistically significant differences(P<0.05).Two patients experienced pin-tract infections,without infection or ulcer recurrence during the follow-up period.(2)These findings indicate that the modified tibial cortex transverse transport combined with antibiotic-loaded bone cement effectively alleviates patients'pain,improves lower limb circulation,controls infections,and promotes ulcer healing.关键词
胫骨横向骨搬运术/抗生素骨水泥/糖尿病足溃疡/血运重建/感染控制/踝关节/组织工程研究/糖尿病并发症Key words
tibial cortex transverse transport/antibiotic-loaded bone cement/diabetic foot ulcer/revascularization/infection control/ankle joint/tissue engineering research/diabetic complication分类
医药卫生引用本文复制引用
刘俊鹏,要星晨,赵会,徐子彧,吴岳,裴福春,张林,杜心如..抗生素骨水泥增强胫骨横向骨搬运治疗感染创面的能力[J].中国组织工程研究,2024,28(29):4599-4604,6.
