中国组织工程研究2024，Vol.28Issue(29)：4710-4716,7.DOI:10.12307/2024.539
骨组织工程支架的制备方法研究进展
Advance in preparation methods of bone tissue engineering scaffolds
摘要
Abstract
BACKGROUND:Due to the small number of autologous bone sources and the risk of immune rejection and disease spread caused by the use of allogeneic bone,artificial bone materials have played an irreplaceable role in bone transplantation today.Along with functional customization,biocompatibility requirements,and the emergence of biodegradable materials,a variety of biomaterials and a variety of preparation methods have emerged. OBJECTIVE:To summarize the preparation methods of scaffolds used in bone tissue engineering,and the advantages and disadvantages,research status and progress of various preparation methods. METHODS:A computer search was conducted on CNKI,WanFang Data,PubMed,and ScienceDirect databases for literature related to bone tissue engineering scaffold from January 2008 to August 2023.Chinese and English search terms were"tissue engineering,bone scaffold,gas foaming,cryotropic gelation,additive manufacturing".After excluding irrelevant and repetitive studies,a total of 80 articles were retained for summary. RESULTS AND CONCLUSION:(1)Compared with the traditional preparation process of scaffolds,the emerging additive manufacturing and electrospinning technologies have shown great potential in the production of complex structures such as bone and cartilage for tissue engineering in recent years,demonstrating enormous potential.(2)In addition to the advantages of speed,precision and the range of materials used,additive manufacturing methods also provide the feasibility of manufacturing highly complex geometry and topologically optimized structures,achieving precise adjustment and high repeatability of the structure.(3)Electrospinning is one of the most adaptable and promising technologies for the production of a series of fiber mats.The nanofiber scaffolds produced by electrospinning are biomaterials with surprisingly similar microstructures to the cytoplasmic matrix.(4)At present,hydroxyapatite and tricalcium phosphate are the best in ceramic materials,and there are a variety of materials in polymer materials,with excellent biocompatibility.(5)Therefore,the selection of materials should be based on a better understanding of their properties,avoiding complexity,and producing more enhanced scaffolds.However,most of the literature reports so far are exploratory in terms of clinical applicability,and the specific diseases for which they are suitable for treatment remain to be tested.The future development of bone scaffolds is reflected in the following aspects:mechanical properties matching the missing bone,controllable degradation rate,strong ability to promote bone regeneration,and specific functions.关键词
组织工程/骨支架/气体发泡/低温凝胶/增材制造/静电纺丝/粘合剂喷射/选择性激光烧结/熔融沉积成型/立体光刻/数字光处理Key words
tissue engineering/bone scaffold/gas foaming/cryotropic gelation/additive manufacturing/electrospinning/binder jetting/selective laser sintering/fused deposition molding/stereolithography/digital light processing分类
医药卫生引用本文复制引用
皇磊,王晓丽,王思明,鲍鑫,周鑫,王犇娣..骨组织工程支架的制备方法研究进展[J].中国组织工程研究,2024,28(29):4710-4716,7.基金项目
江苏海洋大学研究生科研与实践创新计划(KYCX2023-77),项目负责人:皇磊 Graduate Research and Practice Innovation Program of Jiangsu Ocean University,No.KYCX2023-77(to HL) （KYCX2023-77）
