中国临床药理学杂志2024，Vol.40Issue(5)：673-677,5.DOI:10.13699/j.cnki.1001-6821.2024.05.009
奥曲肽注射液经"口服给药"治疗儿童消化道局部疾病的探索
Preliminary study on treatment of local digestive tract diseases in children with octreotide injection through"oral administration"
摘要
Abstract
Objective To explore the feasibility of octreotide injection for"oral administration"in children.Methods The acid resistance stability experiment was divided into experimental group(dissolve octreotide in hydrochloric acid at pH 4.0-4.5)and control group(dissolve octreotide in 0.9％NaCl at pH 7.0-7.5).BN juvenile rats were randomly assigned to the subcutaneous injection group of octreotide(12 μg·kg-1·d-1,subcutaneous injection),the oral administration group of octreotide(12 μg·kg-1·d1-1,oral administration),and the control group(0.9％NaCl)based on gender and body mass grading,with 10 rats in each group.Collect blood samples from 2 children with refractory diarrhea after subcutaneous injection and oral administration of octreotide for 1 hour,and monitor the plasma concentration.Compare the differences in plasma and gastrointestinal concentrations in rats,as well as the differences in plasma concentration in two pediatric patients.Measure the plasma concentration of octreotide using radioimmunoassay.Detection of octreotide concentration in rat intestine by immunohistochemical method.Results The concentrations of octreotide in the experimental group and control group were(810.71±1.91)and(816.55±5.60)ng·mL-1,respectively,without statistically significant difference(P＞0.05).The integrated optical density(IOD)values of octreotide in the subcutaneous injection group and oral administration group were 6.84±0.88 and 9.82±1.07;the concentrations of octreotide in peripheral blood were(26.07±12.19)and(3.53±0.76)ng·mL-1,with statistical significance(all P＜0.001).The plasma concentration of octreotide administered orally and subcutaneously in two pediatric patients were 2.52-3.30 and 22.36-31.68 ng·mL-1.Conclusion"Oral administration"of octreotide exhibits a distribution of"high gastrointestinal concentration/low plasma concentration".High gastrointestinal concentration can treat local gastrointestinal diseases in children and avoid injection pain.Oral administration of low plasma concentration is beneficial for reducing systemic adverse drug reactions in children with growth inhibition.关键词
奥曲肽/生长抑素/口服给药/皮下注射/儿童/血药浓度Key words
octreotide/somatostatin/oral administration/subcutaneous injection/children/blood concentration分类
医药卫生引用本文复制引用
何苗,谢咏梅,汪志凌..奥曲肽注射液经"口服给药"治疗儿童消化道局部疾病的探索[J].中国临床药理学杂志,2024,40(5):673-677,5.基金项目
四川省科技厅自然科学基金资助项目(2019YFG0165) （2019YFG0165）
中央高校基本科研业务费专项资金资助项目(SCU2022F4080) （SCU2022F4080）
