中国美容医学2024，Vol.33Issue(3)：175-178,4.
ⅩⅦ型胶原蛋白在脱发中的作用机制研究进展
Research Progress on the Mechanism of Collagen Type ⅩⅦ in Alopecia
摘要
Abstract
Alopecia is a common skin disease.Its incidence is increasing year by year,and it is developing in a younger trend,which is plaguing more and more people's lives.It is characterized by progressive hair follicle miniaturization and shortening of hair growth period,resulting in loose hair attachment and easy shedding.Collagen type ⅩⅦ is a transmembrane protein located in the hemidesmosomes of the epidermal basement membrane zone,maintaining the tight junction between epidermis and dermis.Recent studies have found that collagen type ⅩⅦ is involved in hair growth and can regulate the quiescence and activation of hair-related cells.Deletion of collagen type ⅩⅦ can lead to alopecia through accumulation of DNA damage effects,imbalance of epidermal cell polarity and inhibition of stem cell competition.This article will review the mechanism ofⅩⅦ collagen in alopecia and provide a direction for the field of hair regeneration.关键词
ⅩⅦ型胶原蛋白/毛囊/干细胞/衰老/脱发/再生Key words
collagen type ⅩⅦ/hair follicle/stem cells/senescence/alopecia/regeneration分类
医药卫生引用本文复制引用
郑屿萍,黄清瑞,张彦峰,张慧敏,何翔..ⅩⅦ型胶原蛋白在脱发中的作用机制研究进展[J].中国美容医学,2024,33(3):175-178,4.基金项目
国家自然科学基金项目(编号:81974570) （编号:81974570）
上海市自然科学基金(编号:21ZR1464000) （编号:21ZR1464000）
上海市科学技术委员会启明星(扬帆专项)(编号:22YF1449500) （扬帆专项）
